以下是关于前B淋巴细胞白血病的详细分点说明：1. 定义与概述 前B淋巴细胞白血病（Precursor B-cell Acute Lymphoblastic Leukemia，B-ALL）是一种起源于骨髓中未成熟前体B淋巴细胞的急性白血病，属于急性淋巴细胞白血病（ALL）的主要亚型（占ALL的80-85%）。 - 细胞来源：B细胞发育早期阶段（前B细胞），停滞在原始...
Velankar, "Precursor B- cell acute lymphoblastic leukaemia with FAB L3 i.e., Burkitt's leukaemialymphoma morphology and co-expression of mono- clonal surface light chains and Tdt: report of a unique case and review of the literature," Pathology, vol. 41, no. 5, pp. 495-498, 2009....
[3]Gökbuget N, Dombret H, Bonifacio M, et al. Blinatumomab for minimal residual disease in adults with B-cell precursor acute lymphoblastic leukemia. Blood. 2018;131(14):1522-1531. Blood. 2019 Jun 13;133(24):...
参考文献: 1. Liu YF, Wang BY, Zhang WN, et al. Genomic Profiling of Adult and Pediatric B-cell Acute Lymphoblastic Leukemia.EBioMedicine.2016;8:173-183. 2. Li JF, Dai YT, Lilljebjorn H, et al. Transcriptional...
Acute lymphoblastic leukemia (ALL) is a heterogeneous group of disorders caused by clonal expansion of immature lymphoid cells. The overall age-adjusted incidence is approximately 1.6 per 100,000...Gastier-Foster, Julie M.Ohio State University...
Precursor B Cell Acute Lymphoblastic Leukemia Acute lymphoblastic leukemia(ALL) is the most common type of childhood cancer, with approximately 6000 new cases diagnosed in the United States each year (Siegel et al., 2014). Most leukemias originate within the B cell rather than the Tcell lineage...
Here we generated 161,986 single-cell transcriptomes to analyse the dynamic changes of B-cell acute lymphoblastic leukaemia (B-ALL) at diagnosis, residual and relapse by combining single-cell RNA sequencing and B-cell-receptor sequencing. In contrast to those at diagnosis, the leukaemic cells at...
Seeger K, Buchwald D, Taube T, et al: TEL-AML1 positivity in relapsed B cell precursor acute lymphoblastic leukemia in childhood: Berlin-Frankfurt-Munster Study Group. Leukemia 13:1469-1470, 1999Seeger, K., Buchwald, D., Taube, T., Peter, A., von Stackelberg, A., Schmitt, G., Ko...
Switches from the lymphoid to myeloid lineage during B-cell precursor acute lymphoblastic leukemia (BCP-ALL) treatment are considered rare and thus far have been detected in MLL-rearranged leukemia. Here, we describe a novel BCP-ALL subset, switching BCP-ALL or swALL, which demonstrated monocytos...
A significant survival improvement finding for adults with newly diagnosed BCR::ABL1-negative B-cell precursor acute lymphoblastic leukemia appears in the New England Journal of Medicine. The practice-changing finding is from the randomized phase 3 study