The past two decades have seen a major progress in the filed of pathphysiology and treatment ofchronic lymphocytic leukemia (CLL). New findings suggested that CLL comprises two separate typesof tumor with different prognosis outcome. CLL formerly was considered an incurable ''oldman'sdisease'' ...
(IGHV) genes, divides CLL into two clinical subgroups, where patients with unmutated IGHV genes (≥98% identity to the corresponding germline gene; ~30–40% of patients) show a considerably worse prognosis than patients with mutated IGHV genes (<98% identity to the corresponding germline gene;...
B细胞慢性淋巴细胞白血病(B CLL) 说明:双击或选中下面任意单词,将显示该词的音标、读音、翻译等;选中中文或多个词,将显示翻译。 1) B cell chronic iymphocytic ieukemia (B CLL) B细胞慢性淋巴细胞白血病(B CLL) 2) CLL 慢性淋巴细胞白血病(CLL)...
In the last two decades, important advances have been made in the biology, natural history, and prognosis of B‐cell chronic lymphocytic leukaemia (CLL). In addition, treatment possibilities for patients with CLL have changed as a result of the identification of prognostic factors for survival and...
Overexpression of cyclin D2 in chronic B-cell malignancies Tumor progression in B-cell chronic lymphocytic leukemia (B-CLL) is thought to result from the gradual accumulation of small resting G0/G1 phase lymphoid c... A Delmer,F Ajchenbaum-Cymbalista,R Tang,... - 《Blood》 被引量: 324...
Results and discussion CCND1 (BCL1), a cell-cycle regulatory protein, is associated with cell proliferation, prognosis and recur- rence of cancer and its over-expression is often found in many different types of tumors (Coco Martin et al. 1999). BCL2 is an anti-apoptotic protein and plays...
结果40例患者中,男性29例,女性11例;中位年龄71.5岁(47~88岁);慢性淋巴细胞白血病(CLL)23例(57.5%),单克隆B淋巴细胞增多症4例(10.0%),Waldenstrom巨球蛋白血症6例(15.0%),边缘区/脾边缘区淋巴瘤5例(12.5%),套细胞淋巴瘤2例(5.0%)。所有患者免疫表型均表达CD19,37例患者细胞膜表面免疫球蛋白轻链限制性表达...
B-cell chronic lymphocytic leukemia (B-CLL) is characterized by the accumulation of monoclonal, slow-dividing CD5+ B lymphocytes in the peripheral blood.1, 2, 3 In most cases, these cells progressively infiltrate the bone marrow and secondary lymphoid tissue, resulting in poor prognosis.1, 2,...
Cytogenetic analysis of patients with chronic B-cell leukemia (B-CLL) indicates that 50% have chromosome abnormalities, while fluorescence in situ hybridization (FISH) and molecular techniques reveal an even higher incidence. Trisomy 12 and deletions or translocation of chromosome 13q14 are the most...
These data suggest that ZO-1, along with CD38 and Zap-70, plays a role in cell cycle regulation in B-CLL and may be used as a prognostic marker in B-CLL monitoring. 展开 关键词: B-cell chronic leukemia Prognosis ZO-1 Connexin43 Gap junction intercellular communication ...