The past two decades have seen a major progress in the filed of pathphysiology and treatment ofchronic lymphocytic leukemia (CLL). New findings suggested that CLL comprises two separate typesof tumor with different prognosis outcome. CLL formerly was considered an incurable ''oldman'sdisease'' ...
6、Pfreundschuh M, Truemper L, Osterborg A, et al. CHOP-like chemotherapy plus rituximab compared with CHOP-like chemotherapy alone in young patients with good-prognosis diffuse large B-cell lymphoma:a randomized controlled trial by the Mabthera International Trial (MInT) Group. Lancet Oncol ...
cell genes and the macrophage genesTNFSF13BandACTN1,immune response 2 (IR2) shows increased expression offollicular dendritic cellgenes and different macrophage genes. Immune response 1 has been linked to a more favorable prognosis, but immune response 2 has been linked to an unfavorable prognosis...
B cell CLL/lymphoma 6 member B (BCL6B) is a novel tumor suppressor silenced in human cancer. In this study, we investigated the functional role and underlying mechanisms of BCL6B in hepatocellular carcinoma (HCC). BCL6B was expressed in normal HCC tissues, but its expression was suppressed...
CD19-targeted CAR T cells have transformed the management of patients with relapsed and/or refractory large B cell lymphoma, and these therapies are increasingly being administered as earlier-line therapies. Nonetheless, the prognosis of these patients is often difficult to predict, with various prosp...
lymphoblastic lymphoma (Bernard et al. 1981). The different manifestations seem to be more related to different age groups and type of precursor cell development than to other biologically relevant phenomena. The prognosis of the T-cell type seems to be a bit less favorable than the B-cell ...
淋巴瘤包括但不限于霍奇金淋巴瘤和非霍奇金淋巴瘤,例如B细胞淋巴瘤(例如弥漫性大B细胞淋巴瘤(DLBCL)、滤泡性淋巴瘤(follicular lymphoma)、慢性淋巴细胞白血病(chronic lymphocytic leukemia,CLL)、小淋巴细胞淋巴瘤(small lymphocytic lymphoma,SLL)、套细胞淋巴瘤(mantle cell lymphoma,MCL)、边缘区淋巴瘤(marginal ...
The past two decades have seen a major progress in the filed of pathphysiology and treatment ofchronic lymphocytic leukemia (CLL). New findings suggested that CLL comprises two separate typesof tumor with different prognosis outcome. CLL formerly was considered an incurable ''oldman'sdisease'' cau...
Interestingly, Lamin B1 dynamics in GC/post-GC B cells translates into CLL, which is a post-GC malignancy. In particular, IGHV-mutated CLL cells, associated with a favourable clinical prognosis and derived from the CD5+/CD27+ post-GC B-cell subset43 displayed significantly higher LMNB1 gene...
(≥98% identity to the corresponding germline gene; ~30–40% of patients) show a considerably worse prognosis than patients with mutated IGHV genes (<98% identity to the corresponding germline gene; 60–70% of patients).12,13IGHV unmutated CLL patients also display a more progressive disease,...