B‐cell CLLchronic lymphocytic leukaemia (CLLKiel classificationHodgkin lymphomaCD20immunoglobulin geneHodgkin lymphoma‐like, CLLB‐cell prolymphocyticmantle cell lymphomafollicular lymphomaThis chapter contains sections titleddoi:10.1002/9781119971771.ch6Gatter, Kevin C...
B-cell chronic lymphocytic leukemia(B-CLL) is one of the most entirely studied form ofhematologic malignancieswith the highest prevalence in patients older than 50 years. The disease presents with progressive accumulation of monoclonal CD5+/CD19+, CD23+, CD21+, CD40+ B cells with prolonged ce...
成熟B细胞白血病主要包括慢性淋巴细胞白血病(chronic lymphocytic leukemia,CLL),B幼淋巴细胞白血病(B-prolymphocytic leukaemia,B-PLL)和多毛细胞白血病(hairy cell leukemia,HCL)。多种FISH探针可用于这些疾病的诊断和细分亚型(表12-8)。 一、慢性淋巴细胞白血病 CLL具有惰性的...
Cases of chronic lymphocytic leukaemia (CLL) with increased prolymphocytes and lymphoid proliferations with relatively similar morphology but with a t(11;14)(q13;q32)(IGH/CCND1) translocation or SOX11 expression are excluded; 【翻译】诊断该病种时...
Chronic lymphocytic leukaemia is the most frequent of these disorders. In the last decade important progress has been made in unfolding the biologic heterogeneity of these disorders, and also in their prognostication and treatment. As a result, the outcome of patients with chronic lymphocytic ...
An important consideration in the design of a tumour vaccine is the ability of tumour-specific cytotoxic T lymphocytes (CTL) to recognise unmanipulated tumour cellsin vivo.To determine whether B-CLL might use an escape strategy, the current studies compared B-CLL and normal B cell MHC class I...
We examined the apoptotic activity of GLA on purified B-cells isolated from patients with B-cell chronic lymphocytic leukaemia (B-CLL) and from normal individuals. GLA significantly increased the degree of apoptosis in B-CLL B-cells after 24 hours of culture. The mean percentage of cells ...
B-Cell chronic lymphocytic leukaemiaregulatory T lymphocytesCD4 cell subpopulationsflow cytometryThe distribution of circulating CD4 lymphocyte subpopulations determined by reactivity with monoclonal antibodies anti-2H4 (CD45RA), anti-UCHL1 (CD45RO), anti-4B4 (CD29) and anti-Leu8, and analysed by ...
Generation in vitro of B-cell chronic lymphocytic leukaemia—proliferative and specific HLA class-II-restricted cytotoxic T-cell responses using autologous dendritic cells pulsed with tumour cell lysate Clin Exp Immunol, 126 (2001), pp. 16-28 View in ScopusGoogle Scholar 16 AM Krackhardt, S Harig...
J Hum Genet (2006) 51:832–838 DOI 10.1007/s10038-006-0029-x SHORT COMMUNICATION Frequent DAP kinase but not p14 or Apaf-1 hypermethylation in B-cell chronic lymphocytic leukemia C. S. Chim Æ T. K. Fung Æ K. F. Wong Æ J. S. Lau Æ R. Liang Received: 17 April 2006 ...