Expression of the chemokine receptors CXCR4 and CCR7 and disease progression in B-cell chronic lymphocytic leuke- mia/small lymphocytic lymphoma. Mayo Clin Proc 2004;79:318-25.Ghobrial IM,Bone ND,Stenson MJ,et al.Expression of the chemokine receptors CXCR4 and CCR7 and disease progression in ...
4g–i). We further analyzed the contribution of several B cell isotypes to the anti-spike responses by examining their immunoglobulin surface expression with flow cytometry (Extended Data Fig. 6c–g). IgG responses dominated the spike reactivity (Extended Data Fig. 6c,d,g), whereas IgM and ...
expression of C-X-C chemokine receptor 5 (CXCR5) [4,5], programmed cell death protein 1 (PD-1), and inducible T cell co-stimulator (ICOS), and low expression of chemokine (C-C motif) receptor 7 (CCR7) [4,5]– the latter enabling Tfh cell migration to and retention in the GC [...
CCR7 expression is required for follicular exclusion of anergic cells, although up-regulation of the receptor does not appear to be necessary. By TUNEL analysis, we observe that excluded anergic cells die in situ at the T/B boundary. We also show that this elimination occurs via a Fas-...
Cyster JG: Chemokines and cell migration in secondary lymphoid organs. Science 1999, 286:2098–2102. Article CAS PubMed Google Scholar Sallusto F, Langenkamp A, Geginat J, Lanzavecchia A: Functional subsets of memory T cells identified by CCR7 expression. Curr Top Microbiol Immunol 2000, 251...
3、ular homing takes center stage in Thelpercell response”综述, 并且提出了Tfh可能是不同于Th1和Th2的一个新的T细胞亚群。直到最近才确定, 滤泡辅助性T细胞(T follicular helper cells, Tfh)是主要负责辅助B细胞的T细胞亚群。Tfh上表达的CD40Lhi和ICOShi分别通过与B细胞上CD40和ICOSL结合, 以及Tfh所分泌的...
Hedgehog (Hh) proteins, such as the indian (Ihh) and sonic (Shh) hedgehog proteins, are stromal cell–derived factors that can regulate survival of CLL and other mature B-cell malignancies.54 ROR1, an oncofetal antigen with CLL-restricted expression, may function as receptor for Wnt5a,55 ...
T follicular helper cell differentiation, function, and roles in disease. Immunity 41, 529–542 (2014). Article CAS PubMed PubMed Central Google Scholar Fan, X. et al. Circulating CCR7+ICOS+ memory T follicular helper cells in patients with multiple sclerosis. PLOS ONE 10, 1–14 (2015)...
The CCR7 level of expression was not altered on the migrated cells. However, CCL19-induced migration was associated with a lowered expression of CRAM, not observed for CCL21. This observation is the result of cell selection rather than of receptor down-regulation as CCL19 does not induce CRAM...
Expression of CD40L by T helper cells is a key ingredient for a functional T cell-dependent germinal centre response through stimulation of CD40 on B cells. Class switch recombination The rearrangement of constant regions at the immunoglobulin heavy chain locus. This results in the splicing out of...