Childhood B-cell precursor acute lymphoblastic leukemia (BCP ALL) is generally a clonal disease in which the number of IGH rearrangements per cell does not... E Csinady,dVVHJ Van,R Joas,... - 《Leukemia》 被引量: 94发表: 2009年 Analysis of clonal rearrangements of the Ig heavy chain lo...
4. Lilljebjorn H, Henningsson R, Hyrenius-Wittsten A, et al. Identification of ETV6-RUNX1-like and DUX4-rearranged subtypes in paediatric B-cell precursor acute lymphoblastic leukaemia. Nat Commun. 2016;7:11790. 5. Suzuki...
The second adult case of NUTM1 fusion-positive B-cell lymphoblastic leukemia: A recurring pattern of poor prognosisdoi:10.1007/s00277-024-06115-xThis manuscript reports a rare case of CUX1 :: NUTM1 -positive B-cell lymphoblastic leukemia (B-ALL) in a 25-year-old female patient who ...
However, its potential role in adults with B-cell acute lymphoblastic leukemia (B-ALL) is unclear. Therefore, we aim to clarify the abnormal expression of the tumor-associated biomarker, RASD1, as a potential target for diagnosis and prognosis in adult Philadelphia-negative B-ALL. Methods The...
www.nature.com/scientificreports OPEN received: 02 April 2015 accepted: 05 January 2016 Published: 09 February 2016 The distinct clinical features and prognosis of the CD10+MUM1+ and CD10−Bcl6−MUM1− diffuse large B-cell lymphoma Ting-Xun Lu1,2,*,Yi Miao1,*, Jia-Zhu Wu...
B cells can contribute to CNS disease either through their actions in the periphery (meaning that they have an ‘outside-in’ effect on CNS immunopathology) or following their compartmentalization within the CNS. The success of B cell-depleting therapy in patients with multiple sclerosis and CNS ...
Clinical use of blinatumomab for B-cell acute lymphoblastic leukemia in adults. Adults with relapsed or refractory B-cell acute lymphoblastic leukemia have a dismal prognosis with a short median overall survival that can be measured in... KJ Lee,Chow,Vivian,... - 《Therapeutics & Clinical Risk...
PURPOSE OF REVIEW: The presence of the Philadelphia chromosome causing the fusion between BCR to ABL1 in B cell precursor acute lymphoblastic leukemias (ALLs) was associated with a particularly bad prognosis, which has been markedly improved with the addition of imatinib to chemotherapy. Recent genom...
Philadelphia chromosome-positive acute lymphoblastic leukemia (PH + ALL) is the most common cytogenetic abnormality of B-ALL in adults and is associated with poor prognosis. Previously, the only curative treatment option in PH + ALL was allogeneic hematopoietic stem cell transplantation (Allo...
Chromosomal abnormalities are established prognostic markers in adult ALL. We assessed the prognostic impact of established chromosomal abnormalities and key copy number alterations (CNA) among 652 patients with B-cell precursor ALL treated on a modern M