Title: EFFICACY AND SAFETY OF BLINATUMOMAB BRIDGING THERAPY AFTERINDUCTION FOR NEWLY DIAGNOSED PEDIATRIC B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA 研究背景 儿童B细胞急性淋巴细胞白血病(B-ALL)患者接受多药化疗会长期经历多种并发症和毒性...
几十年来,细胞毒性化疗一直是治疗 B-ALL 的主要手段,但由于老年(≥60岁)ALL患者疾病具有高危生物学特性,且难以耐受标准化疗,预后通常较差,5年总生存率约为20%。尽管随着临床研究的不断探索,B-ALL的治疗已经取得了长足的进步,但在B-ALL老...
B-cell acute lymphoblastic leukemia (B-ALL) and Burkitt's lymphoma are generally discussed together because the distinction between the two is somewhat arbitrary. Children with an abdominal Burkitt's tumor and >25% marrow blasts are considered to have B-ALL, whereas those with <25% blasts are...
Dr. Lamanna discusses how to sequence Bruton tyrosine kinase (BTK) inhibitors, B-cell lymphoma 2 (BCL2) inhibitors like venetoclax (Venclexta), and newer agents for chronic lymphocytic leukemia (CLL) treatment based on patient factors. In the frontline setting, choice between BTK inhibitor or ...
①效应性B细胞(effector B cell,Beff)可产生自身抗体,如类风湿因子(rheumatoid factor,RF)和抗瓜氨酸蛋白抗体(anti-citrulline protein antibody,ACPA)等,这些抗体形成免疫复合物,沉积在关节中,并通过补体和细胞激活促进炎症过程;②B细胞作为有效的抗原提呈细胞(antigen presenting cell,APC),通过共刺激分子的表达激活...
Expectations regarding where novel therapies such as CAR T-cell therapies will fit into B-cell acute lymphoblastic leukemia treatment algorithms as data from clinical trials continue to evolve.
Human B-cell leukemia货号:KARPAS 231 品牌:ECACC 产品系列:细胞培养物 包装:1支 保存条件:—135℃ 有效期: 产地:英国 产品介绍上一篇: Human Non-Hodgkin̵... Human Neuroblastoma Bo...下一篇: 热门推荐 Human melanoma, metastasis HeLa, genetic modification, a firefly luciferase reporter gene, ...
英文名称 Rat BCL10 (B-Cell Leukemia/Lymphoma 10) ELISA Kit 中文名称 大鼠B细胞淋巴瘤因子10(BCL-10)酶联免疫吸附测定试剂盒 货号 XY-R0093c 种属 Rat/大鼠 规格 96T/Kit (8*12 strips) 48T/Kit (8*6 strips) 检测方法 双抗体夹心法 检测范围 0~ 灵敏度 0 中文名称 英文名称 规格 保存 ELI...
Chimeric antigen receptor (CAR)-T cell treatment as an emerging tumor immunotherapy has produced exciting results in relapsed or refractory B cell acute lymphoblastic leukemia (B-ALL) [1,2,3,4]. However, few data are available on the therapeutic effect of CAR-T against central nervous system ...
A retrospective study led by Northwestern Medicine investigators found that the chimeric antigen receptor (CAR) T-cell immunotherapy drug tisagenlecleucel demonstrated safety and efficacy in pediatric patients with relapsed and refractory B-cell acute lymphoblastic leukemia (B-cell ALL), even when the ...