对复发/难治性前体B细胞ALL患者,tisagenlecleucel是一种合适的治疗选择。 参考文献:V Stackelberg A, Jäschke K, Jousseaume E, et al. Tisagenlecleucel vs. historical standard of care in children and young adult patients...
急性白血病根据恶性细胞起源主要分为急性髓系白血病(acute myeloid leukemia,AML)与急性淋巴细胞白血病(acute lymphoblastic leukemia,ALL)两类。 ALL 主要以原始及幼稚淋巴细胞克隆性增殖为特征。急性B淋巴细胞白血病(B cell-acute lymphoblastic leukemia,B-ALL)是急性...
Adult precursor B-cell lymphoblastic leukemiaCase reportHypercalcemiaOsteolysisPhiladelphia chromosomeOsteolytic bone lesions and hypercalcemia without peripheral blasts B-cell acute lymphoblastic leukemia (B-ALL) is reported in children but rarely seen in adults. We describe the case of a 34-year old ...
综述:倍林妥莫双抗(Blinatumomab)改变新诊断和复发儿童 B 细胞急性淋巴细胞白血病的标准治疗模式 《memo - Magazine of European Medical Oncology》:Blinatumomab is changing the standard of care paradigms of newly diagnosed and relapsed pediatric B-cell acute lymphoblastic leukemia 编辑推荐: 这篇综述聚焦倍林...
在血液疾病的研究领域,B 细胞急性淋巴细胞白血病(B-cell acute lymphoblastic leukemia,B-ALL)一直是困扰医学界的难题。这是一种起源于 B 淋巴细胞的恶性血液肿瘤,多发于儿童和青少年,严重威胁着患者的生命健康。目前,现有的治疗手段虽然在一定程度上提高了患者的生存率,但仍面临诸多挑战。例如,传统化疗药物在杀死癌细...
MATURE B-CELL ACUTE lymphoblastic leukemia (B-ALL) is a rare ALL subtype comprising only 2% to 4% of adults with ALL. The leukemic cells are characterized by L3 morphology according to the French-American-British (FAB) classification,1 with rare exceptions,2, 3, 4, 5 by expression of mon...
Mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer Introduction Acute lymphoblastic leukemia (ALL) is the most common cancer among children and remains a frequent cause of death from cancer before 20 years of age [1,2]. Survival ...
[8]Ting S, Mixue X, Lixia Z, et al. T315I mutation exerts a dismal prognosis on adult BCR-ABL1-positive acute lymphoblastic leukemia, and salvage therapy with ponatinib or CAR-T cell and bridging to allogeneic hematopoietic stem cell transplantation can improve clinical outcomes....
(Extended Data Fig.4g). Although follicular B cells abundantly express CD55, analysis of 85:15Rag1−/−:Cd55−/−BM chimeras that lack CD55 on all B cells and most T cells revealed an intact MZ B cell compartment (Extended Data Fig.4h–j). RBCs make up 99.9% of the cells ...
cell-intrinsic role in the self-renewal of HSCs from the foetal liver and adult bone marrow since its deletion leads to an impaired engraftment in competitive transplants [42]. Hence, Mll is a gene that is essential to maintain the haematopoietic potential during both embryonic and adult ...