5. Suzuki K, Okuno Y, Kawashima N, et al. MEF2D-BCL9 fusion gene is associated with high-risk acute B-cell precursor lymphoblastic leukemia in adolescents. J Clin Oncol. 2016;34(28):3451-3459. 6. Zhang J, McCastlain ...
对复发/难治性前体B细胞ALL患者,tisagenlecleucel是一种合适的治疗选择。 参考文献:V Stackelberg A, Jäschke K, Jousseaume E, et al. Tisagenlecleucel vs. historical standard of care in children and young adult patients...
Two Unexpected Courses in Four Children with Lymphoblastic Leukemia of B-Cell Type (B-ALL)There is now good evidence that ALL of L3 morphology (FAB) is mainly of B-cell origin [4, 7]. B-ALL is one of the fastest growing human malignancies [6, 11]. Prognosis has always been rather ...
There is increasing evidence for a strong inherited genetic basis of susceptibility to acute lymphoblastic leukaemia (ALL) in children. To identify new risk variants for B-cell ALL (B-ALL) we conducted a meta-analysis with four GWAS (genome-wide association studies), totalling 5321 cases and 1...
来自圣犹达儿童研究医院的研究人员针对B细胞前体急性淋巴细胞白血病(B-ALL)中IKZF1基因组改变的异质性与临床预后关联不明确的问题,通过转录组测序和SNP芯片分析了688例患儿数据。研究发现IKZF1缺失(尤其外显子4-7缺失)与基因组IKZF1plus显著增加5年累积复发率(14.8% vs 5.0%, P<0.0001),该结果在独立队列中验证...
研究人员针对 B 细胞急性淋巴细胞白血病(B-ALL)中 t (14;14)(q11;q32) 这种罕见细胞遗传学异常开展研究。在一位 53 岁女性患者中发现该易位及 IGH-CEBPE 融合。患者化疗缓解良好,表明此易位或代表预后良好的 B-ALL 新亚型。 在B 细胞急性淋巴细胞白血病 / 淋巴瘤(B-ALL)中,涉及免疫球蛋白重链(IGH)(14q...
Mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer Introduction Acute lymphoblastic leukemia (ALL) is the most common cancer among children and remains a frequent cause of death from cancer before 20 years of age [1,2]. Survival ...
4. Pan J, Zuo S, Deng B, et al. Sequential CD19-22 CAR T therapy induces sustained remission in children with r/r B-ALL. Blood 2020; 135: 387-91.5. Pan J, Niu Q, Deng B, et al. CD22 CAR T-cell therapy in refractory or relapsed B acute lymphoblastic leukemia. Leukemia 2019...
ALL is a malignant clonal proliferation of lymphoid progenitor cells, most commonly of the B-cell lineage (B-ALL). In the pediatric population, ALL accounts for 81% of childhood leukemias; leukemia overall accounts for one third of cancers diagnosed in children between ages 0–14 years [1]....
[8]Ting S, Mixue X, Lixia Z, et al. T315I mutation exerts a dismal prognosis on adult BCR-ABL1-positive acute lymphoblastic leukemia, and salvage therapy with ponatinib or CAR-T cell and bridging to allogeneic hematopoietic stem cell transplantation can improve clinical outcomes....