864 CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA WITH B-CELL PHENOTYPE (B-ALL)Pediatric Research publishes original papers, invited reviews, and commentaries on the etiologies of diseases of children and disorders of development, extending from molecular biology to epidemiology. Use of model organisms and in ...
5. Suzuki K, Okuno Y, Kawashima N, et al. MEF2D-BCL9 fusion gene is associated with high-risk acute B-cell precursor lymphoblastic leukemia in adolescents. J Clin Oncol. 2016;34(28):3451-3459. 6. Zhang J, McCastlain ...
对复发/难治性前体B细胞ALL患者,tisagenlecleucel是一种合适的治疗选择。 参考文献:V Stackelberg A, Jäschke K, Jousseaume E, et al. Tisagenlecleucel vs. historical standard of care in children and young adult patients...
There is increasing evidence for a strong inherited genetic basis of susceptibility to acute lymphoblastic leukaemia (ALL) in children. To identify new risk variants for B-cell ALL (B-ALL) we conducted a meta-analysis with four GWAS (genome-wide association studies), totalling 5321 cases and 1...
ALL is a malignant clonal proliferation of lymphoid progenitor cells, most commonly of the B-cell lineage (B-ALL). In the pediatric population, ALL accounts for 81% of childhood leukemias; leukemia overall accounts for one third of cancers diagnosed in children between ages 0–14 years [1]....
肿瘤细胞发生预后不良的基因突变可能与低危B-ALL患儿复发相关,最常见突变基因为CREBBP、RAS信号通路基因及TP53、NT5C2。 关键词: 白血病,B细胞;儿童;复发;肿瘤,残余;突变 ABSTRACT ObjectiveTo investigate the clinical and biological characteristics of relapsed childhood low-risk acute B lymphoblastic leukemia (B-...
Carroll AJ, Shago M, Mikhail FM, et al. Masked hypodiploidy: Hypodiploid acute lymphoblastic leukemia (ALL) mimicking hyperdiploid ALL in children: A report from the Children's Oncology Group. Cancer Genet 2019;238:62-68. 5.Harvey RC, Mullighan CG, Chen IM, et al. Rearrangement of CRLF...
4. Pan J, Zuo S, Deng B, et al. Sequential CD19-22 CAR T therapy induces sustained remission in children with r/r B-ALL. Blood 2020; 135: 387-91.5. Pan J, Niu Q, Deng B, et al. CD22 CAR T-cell therapy in refractory or relapsed B acute lymphoblastic leukemia. Leukemia 2019...
[8]Ting S, Mixue X, Lixia Z, et al. T315I mutation exerts a dismal prognosis on adult BCR-ABL1-positive acute lymphoblastic leukemia, and salvage therapy with ponatinib or CAR-T cell and bridging to allogeneic hematopoietic stem cell transplantation can improve clinical outcomes....
该研究表明,在儿童和青少年B-ALL患者中,贝林妥欧单抗桥接allo-HSCT安全有效,NRM较低,并且不影响后续挽救性免疫疗法(包括CAR-T细胞治疗)的疗效。 参考文献 Algeri M, Massa M, Pagliara D, et al. Outcomes of children and young adu...