The first signal required for B-cell activation is delivered through its antigen receptor (top panel). For thymus-dependent antigens, the second signal is delivered by a helper T cell that recognizes degraded f
In multiple myeloma (MM), B cell maturation antigen (BCMA)-directed CAR T cells have emerged as a novel therapy with potential for long-term disease contro
Cancer Cell Int (2021) 21:223 https://doi.org/10.1186/s12935-021-01923-x Cancer Cell International PRIMARY RESEARCH Open Access TriBAFF‑CAR‑T cells eliminate B‑cell malignancies with BAFFR‑expression and CD19 antigen loss Guangchao Li1,2†, Qing Zhang1†, Zhi Liu1...
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In this work, we compare the single-cell transcriptome of tumor-infiltrating immune cells between the two molecular subtypes of lung cancer and seek key cell subsets and their molecular features associated withEGFRmutation. We find that B cells, CXCL13-producing follicular helper CD4+T (TFH)-like...
Bispecific antibodies Bispecific T cell engager antibodies T cell immunity HBV Immune cell activation 1. Introduction The quest for innovative antiviral strategies has become imperative in the evolutionary arms race between viruses and their hosts. Among the many approaches explored, bispecific antibodies ...
8A). Moreover, PB administration could also lead to a significant decrease for the expression of RORγt mRNA in the draining lymph nodes of NC/Nga mice (Fig. 8B). Figure 8 Inhibition of PB on RORγ-mediated Il17 promoter activation. (A) Human T cell derived Jurkat cells were obtained...
1. Janeway, Charles A, and Jr. “B-Cell Activation by Armed Helper T Cells.”Immunobiology: The Immune System in Health and Disease. 5th Edition., U.S. National Library of Medicine, 1 Jan. 1970,Available here. Image Courtesy: 1. “2218 Clonal Selection and Expansion of T Lymphocytes”...
Here we report active T cell–dependent and T cell–independent IgM-to-IgD class switching in B cells of the human upper respiratory mucosa. This process required activation-induced cytidine deaminase (AID) and generated local and circulating IgD-producing plasmablasts reactive to respiratory bacteria...
Traditionally, and currently still, the focus in therapeutic tumor vaccines is on vaccination with tumor antigens, which are processed by antigen-presenting cells (APC's) such as dendritic cells (DCs) to thereby provide for T cell activation and the mounting of an immune response against the tu...