4Deficiencies in absorption, transport and/or metabolismof vitamin B 12 result in its intracellular deficiency lead-ing to anemia, degeneration of nerve fibers, and irrevers-ible neurological damage. 5 Vitamin B 12 deficiency iscommon with aging and is linked to cognitive impair-ment. 6,7 ...
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To date, the cellular basis of these antibody deficiencies and the impact of anti-B cell therapies other than rituximab-induced B cell depletion have not been addressed. In this study, we investigated the efficacy of SARS-CoV-2 mRNA vaccinations in patients with SLE, a B cell-induced disease...
In the following section we profile a number of business model initiatives undertaken by operators to stimulate mobile video service adoption and recommend optimal approaches for mobile operators in reacting to deficiencies in the video maturity of their market. 29 Operator Strategies to Stimulate 4 ...
Public companies are required to disclose risks that can affect the business and impact the stock. These disclosures are known as “Risk Factors”. Companies disclose these risks in their yearly (Form 10-K), quarterly earnings (Form 10-Q), or “foreign private issuer” reports (Form 20-F)...
Chronic hepatitis B is common among patients onrenal dialysis, patients with malignancies receiving chemotherapy and patients who have kidney, heart or livertransplants. IFN has little effect in patients with major immune deficiencies (Davis, 1989). Retrospective analyses have suggested that patients wit...
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B cells have essential functions in multiple sclerosis and in its mouse model, experimental autoimmune encephalomyelitis, both as drivers and suppressors of the disease. The suppressive effects are driven by a regulatory B cell (Breg) population that functions, primarily but not exclusively, via the...
Co-stimulatory molecule expression (CD40, ICOSL) and MHCII levels were assessed throughout GC maturation (Suppl. Fig.12A). With the exception of a slight impairment in ICOSL expression at the pre-GC stage,TfamKO cells did not exhibit any significant deficiencies in these parameters that could ...