The proxim al region of the beta-tubulin C-terminal tail is sufficient for axoneme assembly. Cell Motil Cytoskeleton, 2005; 62, 48-64.POPODI, E. M., H. D. HOYLE, F. R. TURNER and E. C. RAFF, 2005 The proximal region of the β-tubulin C- terminal tail is sufficient for ax...
the centriole attaches to the cell membrane via the distal and sub-distal appendages. Appropriate appendage formation, as indicated inOdf2null mice, is also required for axoneme formation in primary cilia[100]. Many aspects of sperm axoneme assembly are similar to the assembly of other 9+2...
9 RegisterLog in Sign up with one click: Facebook Twitter Google Share on Facebook axoneme Medical Encyclopedia Wikipedia ax·o·neme (ăk′sə-nēm′) n. A bundle of microtubules and associated proteins that makes up the core of a cilium or flagellum, consisting of nine pairs of micr...
8c), a protein required for assembly of the RS3 head and therefore necessary for male fertility in mice24. Whether domain II of AK8 and domains I and IV of AK9 can cycle between open and closed conformations is unclear, but the remaining catalytic domains would, in principle, be ...
Using combinatorial endogenous fluorescent tagging and deletion, we map co-dependencies for assembly into their normal asymmetric localisation. This revealed 15 proteins, 9 known and 6 novel, with a conserved proximal or distal axoneme-specific localisation. Most are outer dynein arm associated and ...
Motile cilia are used by unicellular and multicellular organisms either to propel themselves through fluid or to move fluid across their surfaces. Ciliary motility is driven by a microtubule-based supramolecular assembly known as the axoneme, which consists of nine doublet microtubules (DMTs) surround...
Cells engaged in the process of centriole amplification, revealed by spindle assembly abnormal protein 6 homologue (Sas-6) and deuterosome assembly protein 1 (Deup1) antibodies labeling procentrioles and deuterosomes, respectively, were present at E12.5 together with some scattered multiciliated ...
Taken together, the present study suggested that DNAJB13 might be involved in assembly and stability of axoneme during sperm flagellum development. Mol. Reprod. Dev. 75: 1379-1386, 2008. 2008 Wiley-Liss, Inc.doi:10.1002/mrd.20874Jikui Guan...
Assembly of flagellar radial spoke proteins in Chlamydomonas: identification of the axoneme binding domain of radial spoke protein 3. Radial spokes of the eukaryotic flagellum extend from the A tubule of each outer doublet microtubule toward the central pair microtubules. In the paralyzed... DR Di...
et al. Trichoplein and Aurora A block aberrant primary cilia assembly in proliferating cells. J. Cell Biol. 197, 391–405 (2012). 30. Ibi, M. et al. Trichoplein controls microtubule anchoring at the centrosome by binding to Odf2 and ninein. J. Cell Sci. 124, 857–864 (2011). 31...