Sunkara, Avian antimicrobial host defense peptides: from biology to therapeutic applications, Pharmaceuticals 7 (2014) 220-247, http://dx.doi.org/10. 3390/ph7030220.Zhang G, Sunkara LT. Avian antimicrobial host defense peptides: From biology to therapeutic applications. Pharmaceuticals 2014;7:...
Gram-positive three-component antimicrobial peptide-sensing system. Proc Nat Acad Sci USA 104, 9469–9474 (2007). 12. Hirsch, J. G. Bactericidal action of histone. J Exp Med. 108, 925–944 (1958). 13. Kawasaki, H. & Iwamuro, S. Potential roles of histones in host defense as ...
coli infection, making this peptide an interesting starting point to develop alternatives to antibiotics for use in the poultry sector. Host Defense Peptides (HDPs) are important effector molecules of the innate immune system. These peptides have been found in a wide range of organisms from ...
The high activity of spheniscin against this fungus and other potentially pathogenic microorganisms, such as S. aureus, P. aeruginosa, or Listeria monocytogenes, indicates a potential therapeutic capacity of such peptides. In the mammalian intestinal host defense model presented by Bevins et al. (...
Profiles of expression pattern and tissue distribution of host defense peptides genes in different chicken (Gallus gallus) breeds related to body weight We used chickens with marked differences of body sizes. The non-selected Daweishan mini chickens showed the highest indexes of immune organs and ...
While small-molecule compounds, peptides, and antibodies have been developed for influenza antiviral therapy, the constant mutation of the virus and its ability to evade immune response confound these efforts. Therefore, drugs and vaccines must be regularly updated to address the emergence of new str...
The production of viral peptides, whether from complete or partially deleted proviruses, has been shown to modulate the immune response of host birds. For example, expression of elements containing intact GAG genes can result in the host failing to mount an immune response to horizontally ...
Although CAMPs may have both intracellular and extracellular targets, antimicrobial peptides mainly bind to the anionic constituents of the bacterial cell membrane, which pathogens cannot easily mutate. This enables CAMPs to avoid the common resistance mechanisms observed for classical antibiotics9. However...
Two microliters of peptides mixture was mixed with equal amount of matrix clear supernatant and 0.5 μl of this was spotted on MALDI ground steel target plate. Peptide ion masses were internally calibrated using trypsin autolytic peptides at m/z 702.366 and 3419.542. MALDI analysis was ...
These cassettes may be employed to prepare recombinant peptides. For example, an expression cassette of the invention may be introduced and expressed in a host cell, e.g., an insect cell using a baculovirus vector, so as to yield recombinant avian beta-defensin peptide, a biologically active ...