brassicicola: Alternaria brassicicola; ABA: abscisic acid; ATG: autophagy-related; ATG18a: autophagy-related protein 18a in A. thaliana; ATG8a: autophagy-related protein 8a in A. thaliana; ATG8-PE: ATG8 conjugated with PE; B. cinerea: Botrytis cinerea; BAK1: Brassinosteroid insensitive 1-...
Later, the majority of LBs in the substantia nigra of PD brains were found to be immunopositive for the autophagy-related protein microtubule-associated protein 1A/1B-light chain 3 (LC3) that is responsible for autophagosome formation [6,25,26]. The LC3 signal was present especially in the ...
In this paper, we demonstrate the induction of autophagy in high salt and osmotic stress conditions, concomitant with the upregulation of expression of an Arabidopsis thaliana autophagy-related gene AtATG18a. Autophagy-defective RNAi-AtATG18a plants are more sensitive to salt and drought conditions ...
Moreover, the effects of disease-related changes on either of the pathways and possible basic and clinical outcomes of these changes will be discussed. 1.1. MiRNA maturation pathways In addition to protein-coding genes, the genome of various organisms, ranging from worms to mammals, carry the ...
For instance, in response to DNA damage, the DNA damage protein kinase DNA-PK phosphorylates GOLPH3, leading to an increased interaction with MYO18A, which abnormally increases the tension of Golgi fragmentation [11]. In HCV infection, immune-related guanosine triphosphatase M protein (IRGM) can...
[20]. However, the precise mechanisms of circRNA action, such as their potential role in autophagy-related protein recruitment or translation, remain largely unknown. Further study is needed to fully map circRNA functions, and investigating the roles of circRNAs in mediating autophagy in the context...
7, 9a). Given that the activity of the ULK complex is essential for autophagosome nucleation, whether such conformational changes of the dimeric FIP200 Claw might potentially regulate the ability of FIP200 or other related regulatory protein to activate ULK1/2 for initiating autophagosome formation ...
Autophagy in regeneration of the Drosophila intestine The Drosophila intestine undergoes age related changes that are similar to the mammalian intestine, including increased stem cell proliferation, mis-differentiation of cells, and permeability of the intestinal epithelial barrier resulting in death [119–...
There are a variety of TP53 pathway-related protein mutations in GBM. The TP53 mutation is also one of the criteria used to classify glioma from low to high grades [73]. These findings also showed that the expression and mutation of TP53 can be used to evaluate the feasibility of treating...
The decrease of force in denervated FoxO1,3,4-deficient soleus muscle is related to the presence of FoxO proteins in type I fibres that can promote protein breakdown in these myofibres. It is important to emphasize that the type I fibres express FoxOs because the pro- moter (MLC1f) ...