AuTophaGy-related gene 18 (ATG18), a phosphoinositide-binding protein that functions through the WD40 domain, is required for vesicle formation in autophagy. Here, we isolated and characterized MdATG18a from Malus domestica. Its full-length cDNA is a complete 1281bp open reading frame (ORF) of...
Arabidopsis OXYSTEROL-BINDING PROTEIN–RELATED PROTEIN 2A (ORP2A) was shown to localize alongside an autophagosome-like structure surrounded by the ER (Ye et al.2022
In this paper, we demonstrate the induction of autophagy in high salt and osmotic stress conditions, concomitant with the upregulation of expression of an Arabidopsis thaliana autophagy-related gene AtATG18a. Autophagy-defective RNAi-AtATG18a plants are more sensitive to salt and drought conditions ...
TaATG18a蛋白在高级结构上折叠成与其他WD-40蛋白类似的β-推进器样构象,PI3P结合基序位 于推进器第五叶片的折叠4和第五、六叶片的连接部分,ATG2结合位点位于连接第二叶片和第三叶片的loop上。 TaATG18s能够被白粉菌侵染诱导表达,但具体的诱导表达模式在抗、感白粉病反应之间存在明显差异。在广谱抗 白粉病基因Pm21...
Deficiency of myotubularin-related protein 14 influences body weight, metabolism, and inflammation in an age-dependent manner. Cell Biosci. 5, 69 (2015). PubMed PubMed Central Google Scholar Liu, Q. et al. Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (...
Autophagy-related miRNAs discovered using various independent approaches. Unbiased and high-throughput miRNA or anti-miRNA (e.g. antagomir) library screens, RNA sequence analysis, AGO-CLIP-Seq (RNA sequencing of mature miRNAs following immunoprecipitation of the AGO protein), etc. involved several miR...
IRE1b的RNase活性被ER胁迫激活并参与调控IRE1依赖的mRNA降解(IRE1-dependent decay of messenger RNA, RIDD), 而RIDD则靶向降解自噬启始的负调控蛋白BGLU21(β-glucosidase 21), ROSY1/ML(MD2-related lipid recognition protein)和PR-14(pathogenesis-related protein 14), 该结果表明IRE1b通过降解这些自噬启始...
7, 9a). Given that the activity of the ULK complex is essential for autophagosome nucleation, whether such conformational changes of the dimeric FIP200 Claw might potentially regulate the ability of FIP200 or other related regulatory protein to activate ULK1/2 for initiating autophagosome formation ...
Autophagy-related gene ATM: Ataxia telangiectasia mutated CCND1: Cyclin D1 C. elegans: Caenorhabditis elegans CLL: Chronic lymphocytic leukemia CML: Chronic myelogenous leukemia COX-2: Cyclooxygenase-2 CRC: Colorectal cancer cyto.c: Cytochromec ...
[20]. However, the precise mechanisms of circRNA action, such as their potential role in autophagy-related protein recruitment or translation, remain largely unknown. Further study is needed to fully map circRNA functions, and investigating the roles of circRNAs in mediating autophagy in the context...