Atg101 is an autophagy-related gene identified in worms, flies, mice, and mammals, which encodes a protein that functions in autophagosome formation by associating with the ULK1-Atg13-Fip200 complex. In the last few years, the critical role of Atg101 in autophagy has been well-established ...
The discovery of autophagy-related ('ATG') proteins in the 1990s greatly advanced the mechanistic understanding of autophagy and clarified the fact that autophagy serves important roles in various biological processes. In addition, studies have revealed other roles for the autophagic machinery beyond ...
Autophagy-related (ATG) proteins assist microtubule-associated protein 1 light chain 3B (MAP1LC3B) in coupling with the autophagosome membrane [56,100]. This leads to the conjugation of LC3 to phosphatidylethanolamine, which results in the formation of LC3-II. The binding of the P62 pro...
et al. The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice. J. Clin. Invest. 118, 2190–2199 (2008). CAS PubMed PubMed Central Google Scholar Winslow, A. R. & Rubinsztein, D. C. The Parkinson disease ...
Autophagy-related (ATG) proteins are essential for the formation of autophagosomes, a critical hallmark of the autophagy pathway. The process of autophagosome formation proceeds through the steps of initiation, nucleation, elongation, closure, and ultimately fusion, each of which is regulated by variou...
The differentially expressed ARGs of the GSE57691 dataset were analyzed by protein-protein interaction (PPI), gene ontology analysis (GO), and Kyoto Encyclopedia of Genes and Genomes analysis (KEGG) and were chosen to explore related miRNAs/transcriptional factors. Results. The GSE57691 dataset had...
miR-185-5p mimic, miR-185-5p inhibitor, pcDNA-autophagy-related 101 (ATG101) were respectively transfected into Caco-2cells. Real-time quantitative polymerase chain reaction (RT-qPCR) was performed to assess miR-185-5p expression. Western blot detected the level of ATG101 and tight junction-...
This is further highlighted in the pathogenesis of bone disorders caused by defective osteoclast function which are also linked to mutations in autophagy related proteins, as mentioned in Table 1. Autophagy in bone maintenance Osteocytes are terminally differentiated cells formed from osteoblasts which ...
However, high levels of ROS can cause DNA damage, mitochondrial dysfunction and harmful protein modifications47. Since mitochondria are both the producers and targets of ROS, dysfunctional mitochondria can generate excessive ROS and release apoptosis-related factors such as cytochrome c and AIF (...
Macroautophagy and microautophagy are highly conserved eukaryotic cellular processes that degrade cytoplasmic material in lysosomes. Both pathways involve characteristic membrane dynamics regulated by autophagy-related proteins and other molecules, some