Mitophagy-related regulated cell death: molecular mechanisms and disease implications Molin Yang ,Xiang Wei &Ding-Sheng Jiang Article 05 July 2024|Open Access BNIP3-mediated mitophagy boosts the competitive growth of Lenvatinib-resistant cells via energy metabolism reprogramming in HCC ...
最近,美国辛辛那提大学的Chenran Wang团队在Autophagy发表了题为ATG5 (autophagy related 5) in microglia controls hippocampal neurogenesis in Alzheimer disease的文章,揭示了小胶质细胞ATG5在维持AD小鼠出生后海马神经发生中的重要作用。 Atg5是一个重要的自噬关键因子,可以促进细胞溶酶体与早期自体吞噬体的结合,并最终引...
autophagy related LC3: microtubule-associated protein 1A/1B light chain 3 NCCD: Nomenclature Committee on Cell Death ER: endoplasmic reticulum PNS: perinuclear space ROS: reactive oxygen species CNS: central nervous system ALS: amyotrophic lateral sclerosis References Clarke PG . Developmenta...
EVA1A, EVA1B, EVA1C, FAM208A, FAM25A, FAM75A1, FAPP1, FASTKD5, FBXW28, FIG4, Fucokinase, FYCO1, GABARAP, GABARAPL1, GABARAPL2, Gm104, GMCL1L, GRAMD4, HPS-6, Hrs, INPP1, INPP5E, IP6K1, IPPK, IRGM (immunity-related GTPase family M), ITM2B, ITPK1, KBTBD13, KCTD21,...
and deficient autophagy seriously impacts embryonic differentiation. Autophagy is also closely related to the development of many diseases, including Alzheimer’s disease, cancer, and microorganism infection [3,4]. Autophagy is a highly conserved cellular process in which cytoplasmic materials are degraded...
We found that MoHat1, a histone acetyltransferase (HAT) homolog, had a role in the regulation of autophagy through the acetylation of autophagy related proteins MoAtg3 and MoAtg9. We also found that MoHat1 was subject to regulation by the protein kinase MoGsk1 that modulated the translocation...
Also, the upregulation of autophagy by NLRP3 in these conditions did not generate IL-1β, although mammalian cells can produce IL-1β via an autophagy-based secretory pathway [94]. However, the absence of IL-1β production by OBs could also be related to their incapacity to translate mRNA...
现已报道了超过40个自噬相关基因(autophagy-related gene,ATG)参与细胞自噬调控,且大部分在酵母和哺乳动物之间存在保守性。细胞自噬的核心途径受六个保守的蛋白质复合物调控:(1)ULK1(unc-51 likeautophagy activating kinase 1)-ULK2复合物:自噬诱导阶段(autophagy initiation);(2)ATG9复合物:为自噬体的产生提供膜...
Meanwhile, GSK-3beta inhibition promoted LKB1 translocation from nuclear to cytoplasmic compartment and enhanced LKB1 interaction with its regulatory partners Mouse protein-25 (MO25) and STE20-related adaptor (STRAD). CONCLUSIONS: In conclusion, our data suggest that GSK-3beta plays an important ...
Beneficial Effects of Autophagy in Tanshinone IIA Reducing Endotoxin-induced Acute Lung Injury And Its Related Mechanisms 来自 知网 喜欢 0 阅读量: 45 作者:W Zhou,M Yang,Y Chen 摘要: Objective To investigate the effect of autophagy in Tanshinone IIA reducing endotoxin-induced acute lung injury in...