In addition, we observed fewer autophagy-related structures in the atg8e mutant compared to the WT and in seedlings overexpressing ATG8eΔIDR compared to those overexpressing ATG8e, as evidenced by the ultrastructure of Arabidopsis leaves upon BTH treatment by transmission electron microscopy (TEM)...
Mitophagy-related regulated cell death: molecular mechanisms and disease implications Molin Yang ,Xiang Wei &Ding-Sheng Jiang Article 05 July 2024|Open Access BNIP3-mediated mitophagy boosts the competitive growth of Lenvatinib-resistant cells via energy metabolism reprogramming in HCC ...
Autophagy and autophagy-related proteins in the immune system. Nat. Immunol. 16, 1014–1024 (2015). Article CAS PubMed Google Scholar Dasari, V. et al. Autophagy and proteasome interconnect to coordinate cross-presentation through MHC class I pathway in B cells. Immunol. Cell. Biol. 94, ...
最近,美国辛辛那提大学的Chenran Wang团队在Autophagy发表了题为ATG5 (autophagy related 5) in microglia controls hippocampal neurogenesis in Alzheimer disease的文章,揭示了小胶质细胞ATG5在维持AD小鼠出生后海马神经发生中的重要作用。 Atg5是一个重要的自噬关键因子,可以促进细胞溶酶体与早期自体吞噬体的结合,并最终引...
components are expressed in neurons and neuronal cell lines (Tab.1). While the function of autophagy-related proteins has been described for some, it is still unknown for others (Tab.2). Macroautophagy has been implicated in chronic neurodegenerative diseases and acute neuronal injuries (Tab.3...
Plant growth and development are energy demanding processes. Depending on environmental conditions, or upon shifts of morphogenetic programs related to acceleration of seedling growth or to senescence, a local short-term or a deep long-term energy deprivation can emerge. Autophagy (from the Ancient Gr...
Several kinases, including PERK, protein kinase double-stranded RNA-dependent (PKR), general control non-derepressible-2 (GCN2), and heme-regulated inhibitor (HRI) may phosphorylate eIF2α to prevent protein synthesis and regulate stress-related gene expression. These kinase are respectively activated...
First, we provide an overview of the autophagy machinery, related molecular pathways, and its role in oncology. Then, we describe how nanoparticles can be used to regulate autophagy for cancer treatment. 2. Autophagy machinery There are three distinct types of autophagy in mammalian cells: macro...
3 Glossary Macroautophagy The autophagy-related protein (ATG)-dependent pathway, sequestering cargo into autophagosomes that fuse with lysosomes, in which the cargo is degraded. Proteins, organelles (such as mitochondria) and invading microorganisms are selectively degraded by macroautophagy. Bulk ...
A term commonly used to refer to an autophagic response that is dependent on autophagy-related 5 (ATG5), ATG7, beclin 1 (BECN1) and phosphatidylinositol-3-phosphate (PtdIns3P) production. Rights and permissions Reprints and permissions About this article Cite this article Galluzzi, L., Bravo-Sa...