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However how selective autophagy regulates metabolism remains largely uncharacterized. Here we show that a deficiency in selective autophagy is associated with suppression of lipid oxidation. Hepatic loss oforsignificantly impairs the production of ketone bodies upon fasting, due to decreased expression of ...
damaged mitochondria, and invasive bacteria from cells. Defective autophagy has been directly linked to metabolic disorders. However how selective autophagy regulates metabolism remains largely uncharacterized. Here we show that a deficiency in selective autophagy is associated with suppression of lipid oxidat...
14. Yeo, S.K., Wen, J., Chen, S. & Guan, J.L. Autophagy Differentially Regulates Distinct Breast Cancer Stem-like Cells in Murine Models via EGFR/Stat3 and Tgfbeta/Smad Signaling.Cancer Res76, 3397-3410 (2016)....
Autophagy regulates lipid metabolism Nature, 458 (7242) (2009), pp. 1131-1135 CrossrefView in ScopusGoogle Scholar 91 L.M. Laiglesia, S. Lorente-Cebrián, M. López-Yoldi, et al. Maresin 1 inhibits TNF-alpha-induced lipolysis and autophagy in 3T3-L1 adipocytes J Cell Physiol, 233 (3)...
Singh R, Kaushik S, Wang Y, Xiang Y, Novak I, Komatsu M, Tanaka K, Cuervo AM, Czaja MJ: Autophagy regulates lipid metabolism. Nature. 2009, 458: 1131-1135. 10.1038/nature07976 Article PubMed Central CAS PubMed Google Scholar Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T,...
Autophagy regulates adipose mass and differentiation in mice. J Clin Invest, 2009; 119, 3329-39. [20] Jia Y, Liu T, Zhou L, et al. Effects of Di-(2-ethylhexyl) Phthalate on Lipid Metabolism by the JAK/STAT Pathway in Rats. Int J Environ Res Public Health, 2016; 13, 1085. doi:...
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Lipid metabolism, Lipidomics, Lipids, Liposome, Liver & Digestive Diseases Research, Machine learning in predicting type 2 diabetes, Materials Science & Engineering, Medical and Population Genetics, Meta-analysis of transcriptome data, Metabolism, Metabolomics, Methylation, Microbiologial genetics, microbiome...
Pseudolaric acid B (PAB) upregulates the expression of the transferrin receptor (TFR) to increase the intracellular iron levels, inducing ferroptosis in GBM. Moreover, the increased iron level activates NADPH oxidase 4 (NOX4), resulting in the production of lipid peroxides (NOX converts NADPH ...