In addition to the correlation between autophagy and bone physiology, recent evidence suggests that autophagy plays a fundamental role in the onset and progression of pathological osteoporosis.7,22,23The relationship between the autophagy pathway and osteoporosis was highlighted in a genome-wide associatio...
Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease Alzheimer's disease (AD) is an age-related disorder characterized by deposition of amyloid β-peptide (Aβ) and degeneration of neurons in brain regions su... RG ...
These results suggest that LAMP2A related to chaperone-mediated autophagy (CMA) capacity might play an important role in HD symptom onset and progression.doi:10.1016/j.bbrc.2020.11.042Seung Ho Choi PhD b cKyoungJoo Cho aBiochemical and Biophysical Research Communications...
Although many perturbations in autophagy have been identified, it remains largely unclear how this contributes to disease pathogenesis and progression. Induction of autophagy can be protective in models of neurodegenerative diseases. Thus, understanding how autophagy is affected in these diseases is vital ...
9. Conclusion and future directions Targeting both autophagy and EMT is an intriguing tumor-targeting strategy. Autophagy and EMT are intertwined processes that are critical in the onset and progression of cancer and pose significant challenges to anticancer therapy. Autophagy and EMT: Who controls who...
Numerous studies suggest that autophagy participates in regulating various cellular functions and is closely associated with the onset and progression of various diseases. Wound healing is a complex, multistep biological process that involves multiple cell types. Refractory wounds, which include diabetic ...
1. Mizushima N, Komatsu M. Autophagy: renovation of cells and tissues. Cell 2011;147:728-741. 2. Levine B, Mizushima N, Virgin HW. Autophagy in immunity and inflammation. Nature 2011;469:323-335. 3. Levine B, Kroemer G. Biological functions of autophagy genes: a disease perspective. Ce...
Importantly, the relationship between Mel treatment and VEGF-B signaling pathway has not been reported yet. More recently, the disorder of endoplasmic reticulum (ER) stress and unbalanced autophagy were considered to contribute to the onset and progression of DCM [16, 17]. One form of ER stress...
This review aims to give an intelligible overview of the role of autophagy in cancer formation and progression, describe the complex dual role of autophagy in tumor survival or cell death, summarize the current therapeutic strategies for the treatment of tumors, and, finally, report the most ...
While autophagy is intimately linked to health, the intricate relationship among autophagy, aging and disease remains unclear. This Review examines several emerging features of autophagy and postulates how they may be linked to aging as well as to the development and progression of disease. In ...