The researchers found that activation of the IDO-GCN2 pathway was essential to ensuring autophagy. "The process of autophagy didn't happen in the podocytes without those two," McGaha said. "The podocytes went ahead and died." When they looked at kidney tissue from humans with a wide range ...
The mitochondrial permeability transition in cell death: A common mechanism in necrosis, apoptosis and autophagy. Biochim Biophys Acta 1998;1366(1–2):177-... AP Halestrap,PM Kerr,S Javadov,... - 《Biochem Soc Symp》 被引量: 121发表: 1999年 Susceptibility to programmed cell death in T-...
As his examples show, he does not limit i... LM Kopelman - 《Philosophy Psychiatry & Psychology》 被引量: 0发表: 1994年 Autophagy: not good OR bad, but good AND bad. Autophagy is a well-established mechanism to degrade intracellular components and provide a nutrient source to promote ...
The general properties of senescent cells may suggest that their main role in tumour recurrence does not involve reinstating the cell cycle. Instead, it is more likely to be driven by the release of secretory factors from senescent cells, which may modulate the microenvironment and particularly the...
Autophagy functions as the ‘waste-disposal’ system in cells, clearing damaged macromolecules and organelles that would otherwise become harmful. As a consequence of lysosomal hydrolysis metabolites such as amino acids, fatty acids, nucleosides and sugars are released from the lysosomes, ready to be ...
As a result, mother nature has devised different mechanisms for disposing of mitochondria. We refer to the process removing sick/damaged mitochondriaas mitophagy(a blending of the wordsmitochondriaandautophagy). It involves the mitochondria being engulfed by a structure called aphagophorewhich is then...