C. elegansDauer developmentLipophagyAutophagy involves the sequestration of cytoplasmic contents in a double-membrane structure referred to as the autophagosome and the degradation of its contents upon delivery to lysosomes. Autophagy activity has a role in multiple biological processes during the ...
elegans have been useful to probe the functions of autophagy in an intact multicellular organism that undergoes development to produce different cell types. This review summarizes important themes that have emerged regarding the roles of autophagy in C. elegans in adaptation to stress, aging, normal ...
development of new treatment methods for patients with brain tumors. in this review, we summarize the various mirnas, which are involved in regulating autophagy in brain tumors. moreover, we highlight the role of mirnas in autophagy-related pathways in different cancers. background brain tumors ...
Although prosurvival effects of autophagy in response to starvation are well known in animals, the mechanisms by which animals regulate and coordinate autophagy systemically remain elusive. Using C. elegans as a model system, we found that specific amino acids could regulate starvation-induced ...
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The role of H3K27me3 methylation in cancer development Longjiang Di Wei-Guo Zhu Genome Instability & Disease(2024) Ezurpimtrostat, A Palmitoyl-Protein Thioesterase-1 Inhibitor, Combined with PD-1 Inhibition Provides CD8+ Lymphocyte Repopulation in Hepatocellular Carcinoma ...
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Recent evidence from C. elegans demonstrates that neurons extrude protein aggregates and organelles in membrane-bound vesicles called exophers that are subsequently phagocytosed by Future directions We are only at the inception of our understanding of autophagy in neurons, and how neuron–glia ...
& Sato, K. Degradation of paternal mitochondria by fertilization-triggered autophagy in C. elegans embryos. Science 334, 1141–1144 (2011). 9. Rubinsztein, D. C., Marino, G. & Kroemer, G. Autophagy and aging. Cell 146, 682–695 (2011). 10. Mizushima, N., Yoshimori, T. & ...
Defective autophagy might participate in carcinogenesis, possibly owing to a reduced removal of defective organelles and/or damaged cells. Some chemotherapeutic agents can induce morphological changes, which indicate that autophagic cell death is occurring in the treated cells, but there is no formal pro...