C. elegans avoids toxic chemicals by reversing its movement, and this behavior is mediated by sensory neurons of the amphid, particularly, the ASH neurons 5, 6. Here we show that the PHA and PHB phasmid neurons function as chemosensory cells that negatively modulate reversals to repellents. ...
感覚反応のGCaMP測定:外部からの強い電界(≥3 V / cm)で、Cにさらさelegansは積極的に的確な指示の動きを持つフィールドの負極に向かってクロール。我々は以前、このelectrotactic動作は主に左右ASJニューロンは、動物の頭部12に位置amphid感覚ニューロンによって媒介されることが明らかにな...
Transcription regulatory networks controlling the development and function of amphid sensory neurons in C. elegansVermeirssen, VanessaBabon, JennySequerra, ReynaldoDoucetteStamm, LynnSengupta, PialiWalhout, AJ Marian
NaïveC. elegansare attracted to NaCl concentrations of up to 200 mM but avoid higher NaCl concentrations2,7,8. Attraction to NaCl is primarily mediated by the bilaterally asymmetric ASE sensory neurons15,16. The left ASE neuron (ASEL) produces Ca2+transients in response to increases in NaC...
which are tightly bundled with the dendrites of other amphid neurons, we first had to verify that femtosecond laser ablation exhibits submicrometer resolution inC. elegans. Shenet al. [6] have established that tightly-focused femtosecond laser pulses closer to the ionization threshold (~ 3 nJ in...
elegans, these cues are sensed by a small number of olfactory neurons, each of which expresses several different odorant receptors. The type of behavioral response elicited by an odorant could be specified by the olfactory receptor or by the olfactory neuron in which the receptor is activated. ...
elegans teknikker. Enkelt celle uttrykk er ikke nødvendig (og noen ganger ikke ønskelig hvis flere neurons skal undersøkes, se 12), så lenge som bilder og målinger fra flere celler kan lett skilles. Hvis fluoroforen transgenet ikke er integrert i genomet, kan betydelig ...
elegansamphid sensory neurons that act redundantly and recruit cyclic nucleotide-gated (CNG) or transient receptor potential (TRP) channels to drive both escape and reduced oviposition. Functional homology of the delineated signaling pathways and abolishment of predator-evokedC. elegansresponses by the ...
namely the nematodeCaenorhabditis elegansmapped with the microarray technology initially led to the identification of age-dependent gene expression alterations that characterize the nematode's ageing process. The list of differentially expressed genes was then utilized to construct a network of molecular inte...
In addition to this mechanism, neurons in C. elegans can also reorganize their neural circuits for oxygen sensation in a HIF-1α-dependent manner to allow the nematode to aerotax (migrate towards oxygen) [57]. Glutamate excitotoxicity is a common mechanism of neuronal cell death. Show abstract...