For untreated AIH, acute hepatitis virus A (HAV) and acute hepatitis virus E (HEV) infection are common. Acute HAV infections were higher in treatment-naive pediatric AIH patients. [186], and acute HEV infections were higher in treatment-naive adult AIH patients [187]. For the AIH patient ...
Preceding viral infections have mostly been described in autoimmune hepatitis (AIH) in single cases. We aimed to identify viral infections that potentially trigger AIH, as suggested for hepatitis E virus (HEV) infections. Therefore, antibodies against hepatitis A (HAV), B, C and E viruses; hepat...
Bodenheimer, H.C.GastroenterologySaxena R, Kim Schluger L, Klion F, Scheiner P, Thung S, Bodenheimer Jr HC. Autoimmune hepatitis in the liver allografts of patients transplanted for PBC and overlap syndrome. Gastroenterology 1998;114:A1335....
Other common combinations include pemphigus and autoimmune thyroid disease in type 1 [multiple autoimmune syndrome]; chronic active hepatitis, SLE, pemphigus, bullous pemphigoid, [autoimmune hemolytic anemia], [idiopathic thrombopenic purpura], alopecia areata and Add...
autoimmune hepatitis.20However, transgenic mice with selective overexpression of MHC-II on hepatocytes did not display any predisposition or increased prevalence for autoimmune hepatitis.21Interestingly, in the early stages of PBC, aberrant expression of MHC-II subregion genes (HLA-DP, HLA-DR, and ...
Similarly, being female may further the risk associated with HLA DR4 alleles in type 1 autoimmune hepatitis, since females have a higher frequency of HLA DR4 than men (Czaja and Donaldson, 2002). In MS, there is a strong association between HLA-DR2, DQ6 in females (Celius et al., 2000...
hepatitis(AIH),pr_maryb¨iary cirrhosis(PBC)and the poIymorphisms of cytotoxic T Iymphocyte-associatedantigen-4((了LA一4)genepromoter (一318)andexon1(+49). MEⅡ五oDs:au_4p巾mo自er(.318T/C)and∞n1(+49A/G) poIymorphismsweregenotypedViarestrictIonfragment IengthpolymorphiSm methOdSin62...
About 7% of patients with autoimmune hepatitis have a disease that overlaps with PBC. They may have detectable anti-mitochondrial antibody (AMA) (usually in low titer), histologic findings of bile duct injury and/or destruction, and the presence of hepatic copper. The natural history of the dis...
Although they did find some differences between those with overlap that were AMA-positive versus AMA-negative, a morphologic difference between PBC and AMA-negative overlap syndrome could not be elucidated. Primary biliary cirrhosis-autoimmune hepatitis overlap syndrome: Simplified criteria may be ...
Patients were excluded if they presented with concomitant hepatic damaging factors, such as alcohol consumption, drug abuse, or infection with hepatitis viruses. Additionally, patients diagnosed with primary biliary cirrhosis (PBC) or the overlap syndrome of AIH and PBC (AIH-PBC) were also excluded ...