T cell receptor repertoire expressionT cell receptorsvariable gene usageSummary Activated T-cells are believed to play a critical role in the pathogenesis of autoimmune disease. In experimental allergic encephalomyelitis (EAE), an animal model resembling human multiple sclerosis (MS), there is evidence...
This success inspired the development of CAR T cells to selectively deplete or modulate the aberrant immune responses that underlie autoimmune disease. Promising results are emerging from clinical trials of CAR T cells targeting the B cell protein CD19 in patients with B cell-driven autoimmune ...
T cells in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) have a disease-specific metabolic signature that may explain, at least in part, why they are dysfunctional. RA T cells are characterized by low adenosine triphosphate and lactate levels and increased ...
Natural killer T cells, CD1d, glycolipids, α-galactosylceramide, autoimmunity, immunotherapy, immunomodulationNatural killer T (NKT) cells are an unusual subset of innate immune cells that express a surface receptor generated by somatic DNA rearrangement, a hallmark of cells of the adaptive immune sy...
T cell mediated autoimmune glomerular disease in mice. Curr Protoc Immunol. 2014; 107: 15 27 1-15 27 19.Ooi JD, Gan PY, Odobasic D, Holdsworth SR, Kitching AR: T cell me- diated autoimmune glomerular disease in mice. Curr Protoc Immunol. 2014;107:15.27.1-15.27.19. doi: 10.1002/...
Chimeric antigen receptor T cells (CAR-T cells) are engineered recombinant T cells, which were initially used to treat hematopoietic malignancies and are now widely used in the treatment of various diseases. Considering their intrinsic targeting efficien
During the past 10years, CD4 + CD25 + Foxp3 + regulatory T cells (Treg) have been extensively studied for their function in autoimmune disease. This review summarizes the evidence for a role of Treg in suppression of innate and adaptive immune responses in experimental models of autoimmunity in...
Interferon-Beta Therapy of Multiple Sclerosis Patients Improves the Responsiveness of T Cells for Immune Suppression by Regulatory T Cells. Multiple sclerosis (MS) is an inflammatory autoimmune disease characterized by imbalanced immune regulatory networks, and MS patient-derived T effector cel... Bettina...
"We have known that in autoimmune diseases there are T cells that make us susceptible to disease and T cells that protect us from disease. Now we know how this happens. It opens the field for new and more targeted treatments to specific diseases," he said. ...
High-Throughput T Cell Receptor Sequencing Reveals Differential Immune Repertoires in Autoimmune Thyroid DiseaseAutoimmune thyroid diseasesImmune repertoiresT cells receptorhigh-throughput sequencingBackground: Autoimmune thyroid diseases (AITDs) are chronic autoimmune diseases specific to thyroid and mainly ...