We investigated early behavioural markers of autism spectrum disorder (ASD) using the Autism Observational Scale for Infants (AOSI) in a prospective familial high-risk (HR) sample of infant siblings (N = 54) and low-risk (LR) controls (N = 50). The AOSI was completed at 7 and 14 month...
Psychological markers in the detection of autism in infancy in a large population. Br J Psychiatry. 1996;168(2):158–63. Article CAS Google Scholar Robins DL, Fein D, Barton ML, Green JA. The modified checklist for autism in toddlers: an initial study investigating the early detection of...
3 社会动机理论对自闭症谱系障碍社交缺陷的解释 社会动机理论指出, 自闭症谱系障碍社交缺陷是由于社会动机不足所致。首先, ASD个体的奖赏系统(部分研究认为是杏仁核-纹状体-眶额叶皮层环路)发育异常, 使自身无法从面孔等社会性刺激和社会交往中获得内部奖赏, 从而在行为上表现出社会动机不足的特点, 如社会性注意的缺...
There has been progress in identifying genetic markers for autism, yet there is much still to be determined. There have been multiple theories on environmental factors contributing to autism, with only few showing consistent evidence for their validity. Until quite recently, there has been a ...
Haglund, N., Dahlgren, S., Källén, K. ., Gustafsson, P., & Råstam, M. . (2016). The Observation Scale for Autism (OSA): A New Screening Method to Detect Autism Spectrum Disorder before Age Three Years.Journal of Intellectual Disability - Diagnosis and Treatment,3(4), 230–237...
Both neurocognitive markers distinguished children with an ASD diagnosis at 7years of age from those in the HR-No ASD and LR groups. Exploratory analysis suggested that neurocognitive markers may further differentiate stable versus lost/late diagnosis across the 3 to 7year period, which will need ...
for at least 20% of the recording, were removed from the analysis, and subsequently interpolated. Data were re-referenced to the average of all channels. Data were then epoched according to the event markers for all the conditions considering a pre-stimulus of 800 ms, and their termination...
The substantial phenotypic heterogeneity in autism limits our understanding of its genetic etiology. To address this gap, here we investigated genetic differences between autistic individuals (nmax = 12,893) based on core and associated features of
were examined by measuring size changes between 1- and 2-months of organoid development. Neurogenesis markers at 2-months were examined at the cellular level. At the molecular level, we measured activity and expression of Ndel1; Ndel1 is a prime target for cell cycle-activated kinases; known ...
Hi all! I’m Lily, early career researcher looking at outcomes for autistic people, particularly related to social camouflaging and its impact on mental health and wellbeing/quality of life. I also coordinate an NHS autism assessment clinic for 5-13 year olds in the UK.#AutINSAR ...