Flow cytometry is a useful tool in diagnosing T-cell lymphoproliferative disorders since it is not only able to better characterize T-cell neoplasms but also to resolve some very complicated cases, in particular those in which a small size population of neoplastic cells is available for the ...
As contrasted with their roles in αβ T cell function, presently, our understanding of the extent to which CD1 family members represent ligands for γδ T cells is limited. CD1a-dependent activation of γδ T cells from lungs was seen in one study22. Several tetramer studies showed that ...
(Fig.5a–cand Supplementary Fig.6d), but not affected in intracellular replication or egress from host cells (Supplementary Fig.6e, f). Despite numerous attempts, a complete deletion of the gene could not be obtained. The kinase activity is important for RON13 function as complementation with ...
The myofibromatous stromal tissue derives from the myofibromatous metaplasia of endometrial stromal cells. Some evidence indicates that prolonged oestrogenic stimulation may be significant. In addition, Longacre et al. proposed that if the lesions of APA exhibit markedly complex glands and severe ...
Atypical cytomorphology of Gaucher cells is frequently seen in bone marrow smears from untreated patients with Gaucher disease type 1. Folia Histochem Cytobiol. 2015;53(1):62-69.Markuszewska-Kuczynska A, Klimkowska M, Regenthal S, Bulanda A, Kampe Bjorkvall C, Machaczka M. Atypical cyto...
mediated primarily by (1) donor macrophages, a cell type and response typically seen in non-neuronal allografts [12] and (2) SCs, a cell type atypical to PNAs [15,68,69]. SCs are a specialized PN cell type derived from neural crest cells whose embryonic origins are somewhat unique [70...
pneumoniae-infected children had a CD4 cell count of <20 cells/μL. Additionally, a depleted CD4 associated with advanced HIV disease has been shown to enhance M. pneumoniae establishment in the lungs [40,41,42,43]. However, similarly to C. pneumoniae, the majority of the data on HIV-...
Because of 2 empty cells in the dose-by-design matrix (Table 1; no ineffective or intermediate dose arms exist in active-controlled trials), it was necessary to create a combined categorical dose-design variable instead of considering main effects of dose, design, and dose-by-design ...
Par-4–/– T cells over- produce the Th2 cytokine IL-4,33 whereas PKCz–/– T cells show impaired Th2 polarization and IL-4 secretion ex vivo and in vivo.16 As Par-4 binds and inhibits both aPKC isoforms, understanding the role of this negative regulator might help to predict the ...
Human development begins with the zygote, which divides many times to produce all of the somatic cells. These somatic cells each contain two centrioles, which duplicate in a number-controlled manner from pre-existing centrioles. Since cells require two centrioles for normal division, one would...