Atypical cells (Atyp.C), as a new parameter determined by an automated urine analyzer, can be suspected of being malignant tumor cells. We evaluated the extent to which the Atyp.C can predict the existence of malignant tumor cells.#A total of 3,315 patients (1,751 in the training ...
The urine cytology findings were highly suggestive of a tumor due to the presence of large number of atypical cells with marked hyperchromasia, high nuclear/cytoplasmic ratio in a necrotic background. Scattered cells with viral cytopathic changes were also identified, therefore indicating an ...
Epithelial cells of the visceral layer exhibited swelling with vacuolar degeneration. The presence of foot process fusion was also noted. Prominent hyperplasia of the mesangial cells was observed, without any electron-dense material deposits. Additionally, vacuolar degeneration of kidney tubular epithelial ...
proliferations, but does not sufficiently address the low level of atypia that can be seen in endometrialmetaplasias, loss of polarity, enlargednucleoli, nuclear rounding, and vesicular chromatin (seeFigs. 1–3).3These cytologic changes should be present in the majority of the cells in any give...
Over a period of 7 days, the patient received 2 units of packed red blood cells, 2 units of platelets, 77 g of fibrinogen, 3 units of fresh frozen plasma, and 2800 UI of prothrombin–proconvertin–Stuart factor. In-depth investigations were performed upon admission, including a ...
In the non- producer type, the disorder originates from reticular cells rather than the plasma cells and seems to block the protein production process from plasma cells [2]. The mechanism of the defect of immunoglobulin transport is still unclear and the differential diagnosis of pseudo-non-...
The majority (60 –70%) of CFH mutations is heterozygous missense mutations that cluster in the C-terminal region of CFH, a heparin binding domain (20 –22). Such mutants show decreased binding for glycosaminoglycans, endothelial cells, and C3b, the CFH ligand (20,23–25). In addition to...
Mutations in the gene coding for Bruton’s tyrosine kinase (BTK) have been identified as the cause of XLA. Most affected patients exhibit a marked reduction of serum immunoglobulins, mature B cells, and an increased susceptibility to recurrent bacterial infections. However, the diagnosis of XLA ...
It is associated with decreasing circulating B cells and serum immunoglobulin level at the early stage of the disease [11]. This immunosuppression may lead to viral reactivations, such as from HHV-6, which may in turn lead to more severe systemic immune reaction. DRESS is also associated ...
1 This also applies to rare genetic diseases (RDs) where, with a few exceptions like in muscle or skin diseases,2,3 biopsies are rarely an integral part of diagnostic protocols or available for research purposes. Urine-derived stem cells (USCs) have shown to be a very promising source of ...