Examines massive exfoliation of markedly atypical cells in urine resulting from polyoma virus nephritis in a renal transplant patient. Renal biopsy findings; Urine cytology findings; Observation of marked reactive and degenerative changes in tubular epithelial cells....
The urine cytology findings were highly suggestive of a tumor due to the presence of large number of atypical cells with marked hyperchromasia, high nuclear/cytoplasmic ratio in a necrotic background. Scattered cells with viral cytopathic changes were also identified, therefore indicating an ...
The increase in gastric pH, resulting from the reduction in acid output from the gastric parietal cells.[89]The increase in gastric pH increases the absorption of basic drugs and reduces the absorption of acid drugs; the reduction in gastrointestinal motility, with consequent delayed gastric emptying...
The impairment of beta cells in patients with LADA is a slower process compared to T1DM, which is why patients with LADA do not need insulin right away. By definition, people with LADA can go at least 6 months after diagnosis before they are so insulinopenic that they require insulin to ...
different man- ner, and using retrospective data, Noris et al15 documented a different biomarker of C5 blockade in patients with aHUS, using an ex vivo test that employed vascular endothelial cells that predicted clinical effectiveness of eculizumab in vivo and might guide drug dosing and/or ...
It is associated with decreasing circulating B cells and serum immunoglobulin level at the early stage of the disease [11]. This immunosuppression may lead to viral reactivations, such as from HHV-6, which may in turn lead to more severe systemic immune reaction. DRESS is also associated ...
Differential diagnosis of childhood melanoma includes congenital and acquired nevomelanocytic nevi, the blue nevus (a small, firm, blue papule that consists of deep nevus cells; Fig. 6.17a,b), traumatic hemorrhage (especially under nails, on heels, or on mucous membranes), and a number o...
Functional analysis of the wild-type and mutant proteins was performed in human fibrosarcoma cells. Results: We identified a homozygous founder missense variant, c.133G > T (p.D45Y) in arylsulfatase G (ARSG). All patients shared a distinctive retinal phenotype with ring-shaped atrophy along ...
when the placenta may be subject to attack by the complement and immune system [28]. In addition, the complement pathway may be activated postpartum due to maternal circulation of fetal cells, infections, and hemorrhage [28]. Recently, increased complement activation was identified in a subset ...
On histopathological examination, the cyst wall was lined partly by cuboidal cells and contained hemosiderin-laden macrophages and mononuclear cells. Features of congestion and necrosis were present. There were no endometrial glands/stroma and no malignancy. Discussion Formation of corpus luteum (CL) is...