NXC03 was well tolerated with no neutropenia or hepatotoxicity observed in monkeys.Conclusion:NXC03, an AI-designed attenuated IL-21 mutein, exhibits strong antitumor activity and holds promise as an immunostimulatory agent for combination with checkpoint inhibitors. Given its excellent drug developability...
After administration, the mice were bled for blood (~200 μL) and collected into tubes. Whole blood was allowed to stand at room temperature for 30 min and then centrifuged at 3000 rpm for 15 min. The supernatant was collected for IL-6/IL-10, which are positively correlated with...
If desired, co-stimulatory molecules which improve immunogen presentation to lymphocytes, such as B7-1 or B7-2, or cytokines such as GM-CSF, IL-2, and IL-12, can be included. Optionally, adjuvants can also be included in a composition. Adjuvants which can be used include, but are not...