ATRChk1Cdc25signalingpathway ; G2 / Mcellcycle ; QPCR ; Western blot ; 犇犻犮狋狔狅狊狋犲犾犻狌犿犱犻狊犮狅犻犱犲狌犿 0 引 言 盘基网柄菌( 犇犻犮狋狔狅狊狋犲犾犻狌犿犱犻狊犮狅犻犱犲狌犿 )是单细胞真核原生动物,它的生命周期包含生 长和分化两个特殊的阶段 . 营养丰富的情况下行...
2004. Mismatch repair-mediated G2/ M arrest by 6-thioguanine involves the ATR-Chk1 pathway. Bio- chem Biophys Res Commun 318:297-302.Mismatch repair-mediated G2/M arrest by 6-thioguanine involves the ATR-Chk1 pathway - Yamane, Taylor, et al....
et al. ATR/Chk1/Smurf1 pathway determines cell fate after DNA damage by controlling RhoB abundance. Nat Commun 5, 4901 (2014). https://doi.org/10.1038/ncomms5901 Download citation Received24 January 2014 Accepted02 August 2014 Published24 September 2014 DOIhttps://doi.org/10.1038/ncomms5901...
Inhibition of the ATR/Chk1 pathway induces a p38-dependent S-phase delay in mouse embryonic stem cells. Cell Cycle, 4 (10), 1428–34. View ArticleJirmanova L, Bulavin DV, Fornace AJ., Jr Inhibition of the ATR/Chk1 pathway induces a p38-dependent S-phase delay in mouse embryonic ...
DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells This upregulation requires ATM/ATR/Chk1 kinases. Using an siRNA library targeting DSB repair genes, we discover that BRCA2 depletion enhances Chk1-... H Sato,A Niimi,T Yasuhara,... - 《Nature Communications》...
By contrast, the ATR-Chk1 pathway is the principal direct effector of the DNA damage and replication checkpoints and, as such, is essential for the survival of many, although not all, cell types. Remarkably, deficiency for HRR in BRCA1- and BRCA2-deficient tumors confers sensitivity to ...
[9,46]. These apparently paradoxical observations highlight the fact that the function of A3B is fine-tuned in different contexts, and A3B alone is not sufficient to predict the overall benefits to patients. Perturbation of the ATR-Chk1 pathway induces deleterious consequences, thus can be ...
The ATR-CHK1 DNA damage response pathway becomes activated by the exposure of RPA-coated single-stranded DNA (ssDNA) that forms as an intermediate during DNA damage and repair, and as a part of the replication stress response. Here, we identify ZNF827 as
Previous studies reported that the ATR-CHK1 pathway was required to cope with the high levels of replication stress in cancer cells [12, 29, 59]. Mechanistically, we show that dual CDC7 and ATR or CDC7 and CHK1 inhibition results in an increase in time spent in mitosis and mitotic ...
Our study, thus, identifies a novel relationship between the ATR-CHK1 DNA damage response pathway and HMGA2, which may support the DNA repair function of HMGA2 in cancer cells. Furthermore, our data provide a rationale for the use of inhibitors to ATR or CHK1 and HMGA2 in the treatment...