Conversely, we determined whether gain of function (GOF) of Atr-Chek1 would reduce the regenerative potential of class IV da neurons, which are normally capable of regeneration11. We labeled class IV da neurons withppk-CD4tdGFPand used the following injury paradigm: axotomy was induced at 3rd...
TOP1ATR/CHEK1CD155/TIGIT预后目的1.研究可利霉素主要活性成分异戊基螺旋霉素I(ISP-Ⅰ)对OS细胞的抑制作用及其机制.2.评估OS患者肿瘤组织中TOP1的表达量与患者预后之间的关系.3.检测OS患者手术切除组织中CD155/TIGIT的表达情况及其对患者生存率的影响.方法1.对OS细胞进行了CCK-8增殖试验,伤口愈合试验,Transwell...
MiR-126 negatively regulates PLK-4 to impact the development of hepatocellular carcinoma via ATR/CHEK1 pathway Jie Bao, Yan Yu, Jianan Chen, Yuting He, Xiaolong Chen, Zhigang Ren, Chen Xue, Liwen Liu, Qiuyue Hu, Juan Li, Guangying Cui & Ranran Sun Cell Death & Disease...
Targeted inhibition of ATR or CHEK1 reverses radioresistance in oral squamous cell carcinoma cells with distal chromosome arm 11q loss. Genes Chromo- somes and Cancer 2014;53(2):129-43.Sankunny M, Parikh RA, Lewis DW, Gooding WE, Saunders WS, Gollin SM. 2014. Targeted inhibition of ATR ...
The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation.doi:10.1038/S41467-021-24131-7Feng LiTsz Y. LoLeann MilesQin WangHarun N. NoristaniDan LiJingwen NiuShannon TrombleyJessica I. GoldshteynChuxi Wang...
ATR-CHEK1 pathway is critical for genomic stability.Deregulation of ATR-CHEK1 network may influence breast cancer pathogenesis.High ATR protein is associated with aggressive phenotype and poor prognosis.High cytoplasmic CHEK1 is linked to aggressive breast cancer and poor prognosis.High CHEK1 mRNA is...
Susanne M. GollinRahul Atul ParikhXin HuangGollin SM, Parikh RA and Huang X: Genetic changes in ATM and ATR/CHEK1 as prognostic indicators in cancer. US Patent 20130338212 A1. Filed June 10, 2013; issued December 19, 2013....
Gollin, Susanne M.Parikh, Rahul AtulHuang, XinGollin SM, Parikh RA and Huang X: Genetic changes in ATM and ATR/CHEK1 as prognostic indicators in cancer. US Patent 20130338212 A1. Filed June 10, 2013; issued December 19, 2013....
DNA damage and replication checkpoints mediated by the ATR-CHEK1 pathway are key to the maintenance of genome stability, and both ATR and CHEK1 have been proposed as potential breast cancer susceptibility genes. Many novel variants recently identified by the large resequencing projects have not yet...
Combination of STP-B with pharmacological inhibitors of key components of the DDR pathway (ATR, CHEK1 or WEE1) resulted in synergistic growth inhibition and early apoptosis. Taken together, these findings identify CTPS1 as a promising new target in MM, either alone or in combination with DDR ...