P2rx7基因，又称P2X7R、P2X（7），位于小鼠的5号染色体上，该基因在ATP能量代谢过程中起着至关重要的作用。它是一种在上皮细胞和免疫效应细胞上表达的细胞外ATP门控阳离子通道[1]，能够影响T调节细胞功能[2]、促炎细胞因子的产生、细胞死亡的调节、感染性病原体的消除等等。并且ATP-P2X7R通路在自身免疫性疾...
人体损伤细胞可释放大量ATP到细胞外,作用于T细胞膜上的P2X7受体,促进T细胞产生并分泌免疫活性物质诱发炎症,继而引起发热。下列叙述正确的是( )A. 炎症反应发生时
在神经元方面可以作用于外周神经纤维(ATP有强致痛作用,并且Zn2+/H+SP和BK等致痛物质都可以通过增强P2X受体功能,进一步增强ATP激活电流的作用,增强对伤害性信息的感受)。 ATP和AD在疼痛途径中的作用的假设示意图 P2X7受体主要作用于免疫细胞和胶质细胞,介导促炎细胞因子的释放、细胞增殖和凋亡。其下游通路包括含有ca...
P2X7, as an ion channel activated by extracellular ATP, has been found to play a crucial role in the growth, function, and survival of osteoblasts and osteoclasts in recent studies, holding immense potential for the treatment of osteoporosis. Consequently, P2X7 is...
ATP on tumor and inflammatory cells are mediated by the P2X7 receptor (P2X7R). Aim of this study was to investigate whether: (i) extracellular ATP is a component of neuroblastoma (NB) microenvironment, (ii) myeloid-derived suppressor cells (MDSCs) express functional P2X7R and (iii) the ATP...
1.牙鲆胞外ATP受体P2X7基因cDNA序列,该基因cDNA全长2058bp,含有1743bp的开放阅读框,具有SEQ ID NO.1所示的核苷酸序列。 2.权利要求1所述的基因序列,其中所述的核苷酸序列对应的氨基酸序列如SEQ ID No.2所示;该序列编码580个氨基酸,分子量为65.3KDa,等电点为9.18。 3.权利要求1所述牙鲆胞外ATP受体P2X7基因序列...
We show a distinct mechanism by which Paxillin promotes ATP-induced activation of the P2X7 receptor and NLRP3 inflammasome. Extracellular ATP induces Paxillin phosphorylation and then facilitates Paxillin-NLRP3 interaction. Interestingly, Paxillin enhances NLRP3 deubiquitination and activates NLRP3 inflammaso...
目的:本研究采用葡聚糖硫酸钠(DSS)法复制BALB/c雄性小鼠慢性结肠炎模型,在评价四神丸对结肠炎小鼠疗效的同时,观察树突状细细胞的水平及分化情况,并从干预ATP-P2X7-Panx1信号途径的角度,探究四神丸治疗慢性溃疡性结肠炎(Ulcerative colitis,UC)小鼠的可能作用机制.方法:1.模型复制和给药方法:将40只SPF级BALB/c健康...
Basal proliferation of BrdU+ cells was also sensitive to blockade of ATP-P2X7 signaling. Furthermore, TNF activation of P2X7 receptors appear to regulate AQP4 expression through protein kinase C cascade and down regulation of AQP4 expression can reduce TNF-stimulated BrdU+ cell proliferation. Taken ...
P2X7 receptorAntagonistsInflammationCancerThe P2X receptor 7 (P2X7R) is a plasma membrane receptor sensing extracellular ATP associated with a wide variety of cellular functions. It is most commonly expressed on immune cells and is highly upregulated in a number of human cancers where it can play...