Atherosclerosis has been implicated as a cause of valvular calcification. The aim of this study was to determine whether atherosclerotic calcification in multiple vascular areas is significantly associated with aortic or mitral annular calcification independent of traditional risk factors. A total of 1242 ...
VASCULAR smooth muscleMUSCLE cellsEMPAGLIFLOZINARTERIAL calcificationCALCIFICATIONSGLT-2 inhibitors, such as empagliflozin, have been shown to reduce the occurrence of cardiovascular events and delay the progression of atherosclerosis. However, its role in atherosclerotic calcification remains un...
a tightly regulated process recapitulating embryonic bone formation, in this study, RNA-seq data generated from rabbit models with inherited or induced hyperlipidemia and atherosclerosis were used, to investigate bone formation related signals and biology processes in atherosclerotic vascular calcification. ...
Serum OPG level therefore may reflect inflammation and matrix degradation as well as vascular calcification. Thus, therapeutic strategies aimed at increasing local OPG concentrations in bone and the vascular wall using gene therapy with human recombinant OPG, might be protective against osteoporosis and ...
Association between the MGP gene rs1800801, rs1800802, rs4236 polymorphisms and vascular calcification and atherosclerotic disease was inconsistent. To clarify precise association, we performed this meta-analysis. Medline, Embase and China Knowledge Reso
These results may contribute to better understanding of vascular homeostasis and assist in the development of novel therapies for atherosclerosis. S tem C ells 2018;36:1075–1096Cho Hyun‐JaiDepartment of Internal MedicineLee Jin‐WooStrategic Center of Cell & Bio TherapySeoul National University ...
In matrix Gla protein-deficient mice, a model of human vascular calcification, mice lacking HDAC9 had a 40% reduction in aortic calcification and improved survival. This translational genomic study identifies the first genetic risk locus associated with calcification of the abdominal aorta and ...
Heart valve calcification in young patients with systemic lupus erythematosus: a window to premature atherosclerosis vascular morbidity and a risk factor for all-cause mortality. Atherosclerosis. 2006;185:406e412.Y. Molad, N. Levin-Iaina, M. Vaturi, J. Sulkes, and A. Sagie, "Heart valve ...
Runx2 deletion in smooth muscle cells inhibits vascular osteochondro- genesis and calcification but not atherosclerotic lesion formation. Cardiovasc Res (2016) 112(2):606-16. doi:10.1093/cvr/cvw205Lin ME, Chen TM, Wallingford MC, Nguyen NB, Yamada S, Sawangmake C, Zhang J, Speer MY and ...
Grade 4 lesions were considered as severe calcifications and lesions below grade 4 as moderate calcifications. After induction of anesthesia for open revascularization of the lower limbs, peripheral blood samples were collected. After the skin incision on the marked operated side, subcutaneous fat and...