LDL-cholesterol (LDL-C) levels, even those within the range currently considered normal, are associated with subclinical atherosclerosis in the absence of conventional cardiovascular risk factors, according to new data from the PESA study. "Our findings suggest that the 'normal' LDL-C levels we ...
Normal LDL-Cholesterol Levels Are Associated With Subclinical Atherosclerosis in the Absence of Risk Factors Author links open overlay panelLeticiaFernández-FrieraMD, PhDabcValentínFusterMD, PhDadBeatrizLópez-MelgarMD, PhDabBelénOlivaMScaJosé M.García-RuizMDaceJoséMendigurenMDfHéctorBuenoMD, PhDag...
Accordingly, estrogen receptor alpha promoter methylation and expression are increased and decreased, respectively, in atherosclerotic compared with donor-matched and artery type-matched normal controls (Post et al., 1999; Valencia-Morales Mdel et al., 2015). Diabetes is one of the cardiovascular ...
Analysis by ELISA has revealed that virtually all normal human sera contain varying levels of naturally occurring IgG and IgM autoantibodies to cholesterol. Naturally occurring autoantibodies to cholesterol are also observed in pigs, but not in guinea pigs. Possible implications of these investigations ...
The present study describes the cholesterol absorption by hyperlipidemia atherosclerosis prone (LAP) Japanese quail to address their high susceptibility to experimental atherosclerosis. The apparent cholesterol absorption rate of LAP quail was compared with that of commercially available (CA) Japanese quail....
Beyond cholesterol metabolism, other physiological processes are also regulated by PCSK9, such as adipogenesis modulation, immune response, and interaction with many other cellular receptors, including oxLDL receptor-1 (LOX-1), VLDL receptor (VLDLR), and ApoE receptor 2 (ApoER2), CD36, and LDL...
The global population of older individuals is growing, and ageing is a key risk factor for atherosclerotic cardiovascular diseases. Abnormal accumulation of senescent cells can cause potentially deleterious effects on the organism with age. As a vital ma
ASCVDrisk as defined by the 2013 ACC/AHA guideline includes nonfatal myocardial infarction (MI),Coronary Heart disease(CHD) death, and nonfatal and fatal stroke. In contrast, the traditionalFramingham risk score(as recommended by the National Cholesterol Education Program [NCEP] Adult Treatment Pane...
normal fodder without any treatment.The pathological exˉamination of iliofemoral artery was made at the end of experiment.The changes of symptom were observed and the levels of total cholesterol(TC),triglyceride(TG),endothelin(ET)and nitric oxide(NO)were determined successively during the process....
(Fig. 1B). The relative expression level of miR-155 in 17 pairs of atherosclerotic lesions and normal veins from the same patients were also detected by qRT-PCR and the results showed that the miR-155 level was significantly increased in the atherosclerotic lesions compared with the normal ...