Atherosclerosis: Preventing plaque rupturethalidomidemouse embryonic cellsdrug resistanceteratogenicsuperoxideglutathioneantioxidant defenseapoptosisThe article discusses a study on how darapladib, a lipoprotein-associated phosphatase A2 (Lp-PLA2), prevents the formation of unstable plaques in heart disease such ...
A form of arteriosclerosis characterized by the presence of lesions (called plaques) on the innermost layer of the walls of large and medium-sized arteries. The plaques contain lipids, collagen, inflammatory cells, and other substances and can impede blood flow or rupture, leading to serious probl...
"动脉粥样硬化"Atherosclerosis是"心血管系统疾病"Cardiovascular Disease中最常见的疾病: It is a disease in whichplaque("斑块") builds up inside your arteries. The first threecomplications("并发症") are: 1.Occlusion("堵塞") of vessel 2.Disruption of plague 3...
Atherosclerosis is a progressive disease, and although the plaque may occupy an increasing percentage of the lumen of the artery, it generally is not associated with clinical symptoms until stenosis approaches 70% or greater. Plaque rupture is a more acute phenomenon that can lead to an abrupt re...
Fibrous plaque. As cells keep building up, the fatty streak gets bigger. Muscle cells grow over the top of it, forming what's called a fibrous plaque. This narrows your artery, making it harder for blood to flow. Complicated lesion. This forms when the fibrous plaque ruptures, exposing th...
S. Insights into the role of infection in atherogenesis and in plaque rupture. Circulation 119, 3133–3141 (2009). Article CAS PubMed Google Scholar Andraws, R., Berger, J. S. & Brown, D. L. Effects of antibiotic therapy on outcomes of patients with coronary artery disease: a meta-...
threemainkindsofcardiovasculardisease:grossnecrosisofthemyocardium,asaCoronaryarteryresultofinterruptiondisease:Stableplaquesintheheart'sarteriesofthebloodsupply(chestcauseanginatopainonexertion).thearea.plaqueruptureSuddenandclottingcausesheartmuscletodie.Thisisaheartattack,ormyocardialinfarction.Infarctionisa...
Moreover, we found that senescent human vascular smooth muscle cells can actively promote the occurrence of atherosclerosis and plaque rupture by establishing the SASP. The SASP is characterized by sustained secretion of a variety of inflammatory factors and chemokines, which are regulated by the autoc...
offbloodflowandcancausepain.Blockagescanalsosuddenlyrupture,causingbloodtoclotinsideanarteryatthesiteoftherupture.-8AtherosclerosisandPlaqueAttacks Plaquesfromatherosclerosiscanbehaveindifferentways. Theycanstaywithinthearterywall.There,theplaquegrowstoacertainsizeandstops."Becausetheydon'tblockbloodflow,thesepla...
Certain types of plaques—those rich in lipids and surrounded by a thin fibrous cap—are the most prone to rupture. Numerous factors, intrinsic and extrinsic to the plaque itself, interact to cause the formation of a vulnerable lesion and, ultimately, plaque disruption. Fissuring or rupturing ...