Therefore, the main objective of this chapter is to offer an integrated review of the main factors that participate in the formation of the atherosclerotic plaque with specific focus on the endothelium.Protásio Lemos da LuzAntonio Carlos Palandri Chagas...
Featured Glutamine–glutamate imbalance in the pathogenesis of cardiovascular disease Glutaminase-2 (GLS2) is crucial for glutamine metabolism and its deficiency causes increased plasma glutamine levels, disrupted extracellular matrix remodeling and accelerated plaque progression. Findings reveal a metabolic link...
served by the artery, thereby causing severe tissue damage. In addition, a disturbance to the endothelium may result in the formation of a blood clot (thrombus) at the site of a plaque, likewise obstructing the channel or breaking loose from the site and causing a catastrophic blockage ...
Atherosclerosis is the process of plaque formation including various cells, lipids, and debris tissue in the vascular intima,1which is identified as a chronic vascular inflammation mediated by traditional and nontraditional risk factors.2Atherosclerosis was traditionally regarded as a disease of cholesterol...
Manganese strengthens arterial tissues, making them more resistant to plaque formation. Magnesium Requirement Experimental studies have demonstrated a correlation between magnesium deficiency and atherosclerosis, but without any clear evidence to determine the mechanisms involved. Magnesium deficiency may affect...
An Odyssey of Plaque to Stroke: A Lipid Perspective. Inflammation andatherosclerosis: novel insights into plaque formation and destabilizati... RM Adibhatla - 《Athero Org》 被引量: 0发表: 0年 Cholesterol crystal induced arterial inflammation and destabilization of atherosclerotic plaque Evolution of...
Widely used coronary artery lumen, vascular wall and atherosclerotic plaque formation [77, 78]is the most effective visualization method for early diagnosis of atherosclerosis [79,80,81]. However, IVUS not only requires skilled clinical skills and professional knowledge of image interpretation, but ...
Atherosclerosis, characterized by endothelium damage, lipid accumulation and atherosclerotic plaque formation in the intima, could disrupt blood flow and lead to atherosclerotic cardiovascular diseases (Libby et al., 2019). In addition, the balance between pro-inflammatory and anti-inflammatory cytokines pl...
Mitochondrial dysfunction is implicated in atherosclerosis development and progression [136]. Impaired mitochondrial function promotes lipid accumulation, oxidative stress, inflammatory responses, and proliferation of vascular smooth muscle cells, all of which contribute to plaque formation and destabilization [13...
Studies confirm that the death of these cells is closely related to the formation of necrotic cores and plaque instability in advanced atherosclerotic lesions [97, 100]. The migration of VSMCs from the media into the intima is a pivotal feature of arteriosclerosis. TNF-α can induce ...