In our study, we identified compound 1 as an inhibitor of the ATG12-ATG3 protein–protein interaction. We focused on the systematic modification of the original hit 1 , a casein kinase 2 (CK2) inhibitor, to find potent disruptors of ATG12-ATG3 protein–protein interaction. A systematic ...
The ubiquitin-like molecule ATG12 is required for the early steps of autophagy. Recently, we identified ATG3, the E2-like enzyme required for LC3 lipidation during autophagy, as an ATG12 conjugation target. Here, we demonstrate that cells lacking ATG12–
Two autophagy-related ubiquitin-like systems have unique features: the E2 enzyme Atg3 conjugates the ubiquitin-like protein Atg8 to the lipid phosphatidylethanolamine, and the other ubiquitin-like protein conjugate Atg12–Atg5 promotes that conjugase activity of Atg3. Here, we elucidate the mode of...
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ATG3 题目: 由A,T,G3种碱基构成的核糖核苷酸共有几种( ) A、2 B、4 C、5 D、8 免费查看参考答案及解析 12345678910下一页 共2000条数据 亲,您把题目复制到这里 搜一搜,就有答案。免费的哦
Instead disruption of the ATG12-ATG3 complex leads to a highly fragmented mitochondrial network that is incapable of fusion, increased in mass and defective in mitochondrial autophagy. These phenotypes also correlate with resistance to mitochondrial cell death.;In summary, we have demonstrated evidence ...
Murrow L, Malhotra R and Debnath J: ATG12-ATG3 interacts with Alix to promote basal autophagic flux and late endosome function. Nat Cell Biol 17: 300-310, 2015.Murrow L, Malhotra R, Debnath J. ATG12-ATG3 interacts with Alix to promote basal autophagic flux and late endosome function. ...
Atg12Atg3背景中波紫外线主要作用于表皮,角质形成细胞是其重要的靶细胞,可以引起角质形成细胞内的蛋白损伤,而有效地清除损伤蛋白对于维持细胞内环境的稳定至关重要.p62是一种具有多种生物学功能的泛素结合蛋白,其C端的泛素相关(ubiquitin-associated, UBA)结合区可识别错误折叠蛋白的泛素部位,p62通过LC3相互作用区域(LC3...
ATG12, an ubiquitin-like modifier required for macroautophagy, has a single known conjugation target, another autophagy regulator called ATG5. Here, we identify ATG3 as a substrate for ATG12 conjugation. ATG3 is the E2-like enzyme necessary for ATG8/LC3 lipidation during autophagy. ATG12-ATG3 ...
Identifying a selective inhibitor of autophagy that targets ATG12-ATG3 protein-protein interactionAutophagy inhibitioncancerdrug screenLC3Bpancreatic cancerprotein-fragment complementation assaysmall moleculesAbbreviations: ANOVA: analysis of variance; ATG: autophagy related; CQ: chloroquine; GFP: green ...