Humbert S, Saudou F (2006) The ataxia-ome: connecting disease proteins of the cerebellum . Cell 125 ( 4 ): 645–647.Humbert S, Saudou F. The ataxia-ome: connecting disease proteins of the cerebellum. Cell 2006;125(4):645-7.
Ataxia describes the uncoordinated or unsteady movement of an affected person due to the brain's failure to regulate the body's posture and regulate the strength and direction of limb movements. Ataxia is usually a consequence of disease in the brain, specifically in the cerebellum. Ataxia may a...
Deep brain stimulation (DBS) relieves motor dysfunction in Parkinson’s disease, and other movement disorders. Here, we demonstrate the potential benefits of DBS in a model of ataxia by targeting the cerebellum, a major motor center in the brain. We use
Ataxia is a progressive degenerative disorder of the nervous system caused by damage to the cerebellum or other parts of the brain. Cerebellar ataxia symptoms can include a wide range of disorders, primarily related to coordination and speech. Currently, there is no cure for the disorder, and tr...
This type of ataxia is genetic, or inherited, and it’s caused by a defect in a gene called FXN. It’s a degenerative disease, meaning that the condition worsens over time, and it damages the cerebellum, spinal cord, and peripheral nerves. Symptoms usually start in childhood, between ages...
2.Any of various degenerative, often hereditary, disorders that are characterized by ataxia and are frequently associated with cerebellar atrophy. [Greekataxiā,disorder:a-,not; seea-1+taxis,order.] a·tax′icadj.& n. American Heritage® Dictionary of the English Language, Fifth Edition. Copyri...
Since the time of Holmes (1939), it has been applied more specifically to clumsiness that is due to lesions of the cerebellum and its immediate connecting pathways, of proprioceptive sensory pathways or sometimes of the vestibular system. In order to identify the presence of ataxia, it should ...
The clinical category of immune-mediated cerebellar ataxias (IMCAs) is now recognized after 3 decades of clinical and experimental research. The cerebellum gathers about 60% of neurons in the brain, is enriched in numerous plasticity mechanisms, and presents a large variety of antigens at the neu...
Due to the varying connectivity between the cerebellum and the motor system, lesions in different areas of the cerebellum result in different symptoms (Dichgans, 1984;Timmann et al., 2009). These can be summarized as: • Vermis: ataxia of balance and gait and dysmetric saccadic eye movement...
Cerebellar ataxia is a form of ataxia that originates from dysfunction of the cerebellum, but may involve additional neurological tissues. Its clinical sym