BBS treatment leads to decrease in p53 levels and astrogliosis marker GFAP.Polina, RabinovichToidmanInna, RabinovichNikitinAssaf, EzraBeka, BarbiroHilla, FogelInna, SlutskyBeka, Solomon
We used immunohistochemistry to examine the differential distribution of the astrocyte marker glial-fibrillary acidic protein (GFAP) in the brains of diet-induced or genetically obese mice compared with their respective lean controls to determine whether different nuclei of the hypothalamus showed ...
In addition to adult astrocytes, Mlc1-tTA also targeted astrocyte-like adult neural stem cells (NSCs), as indicated by the presence of YFP-labeled cells coexpressing the NSC marker, nestin (Supplementary Figure 1a and b). Nevertheless, nestin+ cells in the normal adult brain were strictly ...
the most connected nodes in the network were related to pro-inflammatory processes and the astrocytic marker GFAP. We used the iNode enrichment analyses to infer the molecular drivers of reactive astrogliosis in four datasets: an LPS-induced mouse model of endotoxemia-associated neuroinflammation, the ...
GFAP promoter activation was used as a surrogate marker for host compartment astrogliosis to assess tumor progression. Here we show that these GFAP-luc; Rag2-/- mice injected with malignant glioma cells can be used to monitor and quantify tumor-induced astrogliosis response of the host. Analysis...
This analysis examined a set of 181 genes combined from canonical EMT-related marker genes (Zeisberg and Neilson, 2009) and the EMT gene set enrichment analysis (GSEA) dataset for genes defining EMT in wound healing, fibrosis, and metastasis (Subramanian et al., 2005). Changes in gene ...
Background and purpose Several investigations have reported that melatonin is involved in the amelioration of the inflammatory process, improvement of myelin function, and regeneration in the central nervous system (CNS). The current study aimed to evaluate the protective effect of melatonin in cuprizon...
In operant learning conditions, as well as in uninjured human cortical tissue, it should be noted that the astrocyte marker that was used to co-label cells undergoing astrogenesis with BrdU was GFAP. However, it is not certain whether upregulation of intermediate fi laments GFAP and vimentin ...
Four weeks following occlusion we collected, processed, and immunolabelled tissue using an antibody directed at the glial fibrillary acidic protein (GFAP), an astrocyte specific cytoskeletal protein marker. We investigated GFAP changes in 13 regions in both the contra- and ipsi-lateral hemispheres ...
A Analysis of global levels of cell type-specific transcripts from sorted mouse microglia RNA-seq samples using geometric mean of the normalized counts of cell type marker genes of Drd1 (direct)-MSNs, Drd2 (indirect) -MSNs, astrocytes and microglia. B Volcano plot illustrating the DEGs ...