Reliance on animal testing for drug development has long been a subject of ethical scrutiny and scientific debate. While the age-old practice contributes much to medical advancement, it raises legitimate concerns about animal welfare and the precision of toxicologica...
In practice, however, the entrance of the transposase requires permeabilization of the nuclei, which causes fragments of DNA and RNA to escape, meaning that the buffer is a soup of RNA and DNA molecules from different cells [1]. As a result, nuclei-free droplets can exhibit non-zero read ...
The black vertical line (A, lower plots, and B) is the mean technical error for a given drug and the red vertical line demarcates the 90th percentile error across technical replicates (meaning that the error for 90% of GR values or GR metrics is below that value); a blue circle ...
naturally in the mammalian, especially human, body, including (1) the purification from other associated structures or compounds or (2) the association with structures or compounds to which it is not normally associated in the mammalian, especially human, body, are within the meaning of “...
Unless defined otherwise, technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art(s) to which this invention belongs. Although any methods, devices, and materials similar or equivalent to those described herein can be used in th...
(Supplementary Note S1). However, eNP preparations require numerous centrifugal steps with the consequent loss of nanoparticles, meaning an inevitable reduction of solid content from step to step. This issue would be addressed by enabling quantification of the number of eNPs per microliter of ...
[0215] All headings are for the convenience of the reader and should not be used to limit the meaning of the text that follows the heading, unless so specified. [0215] 权利要求:Claims (79)[1" id="US-20010006820-A1-CLM-00001] 1. A method of reducing undesired light emission from a...
Title: Abstract: Disclosed herein are means for the detection and characterization of neurotoxins such as botulinum neurotoxin (BoNT) or tetanus neurotoxin. The present disclosure provides methods for determining potency and activity of neurotoxins in vitro and in vivo. Also disclosed are polypeptides co...
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs. Although any methods and materials similar or equivalent to those described herein can also be used in the p...
Further, unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which the invention pertains. As used in this specification and the appended claims, the singular forms “a,”“an,” and “...