DIB-mediated Hofmann rearrangement at the primary amide moiety of an Asn side chain afforded a five-membered N-acylurea intermediate that was successively hydrolyzed into two peptide fragments. The Asn-selective peptide bond cleavage proceeded in aqueous neutral solution at 37 °C for various ...
Crystal structure of vancomycin Results: Using low-temperature synchrotron X-ray data combined with new ab initio techniques for solving the crystallographic phase problem, we have succeeded... M Sch?Fer,TR Schneider,GM Sheldrick - 《Structure》 被引量: 341发表: 1997年 Neighboring side chain effec...
Additionally, for at least two positions, 170 and 219, a mismatched polar residue also promoted conversion, indicating that the side chain structure did not require a precise match with the PrPSc seed but did require a structurally similar residue. Notably, the position of the Asn/Gln residue ...
γl (C-7eq) backbone structureSide-chain conformationSide-chain model: propanoic acidamideAb initio molecular computations were carried out on N-formyl-l-asparaginamide at the RHF/3-21G level of theory and N-acetyl-l-asparagine N-methylamide at the RHF/3-21G and RHF/6-31G(d) levels ...
The amino acid L-asparagine is a structural analog of L-aspartic acid, where the side chain of the carboxylic acid moiety is amidated, to give a terminal amine group. This renders L-asparagine neutral at physiological pH. The amide group of asparagine is derived from glutamate, in the reacti...
Figure 1 The chemical structure of the L-asparagine ; View all Synthesis and Metabolism A major route for Asn biosynthesis is via the ATP-dependent transfer of the amide group of glutamine to the β-carboxyl group of aspartate by the action of asparagine synthetase[AS]. So far, two types...
Until recently, the main focus has been on measurement of dipolar couplings in the protein main chain. However, with the aim of more complete protein structure, it is also essential to have information on the orientation of protein side chains. In addition, residual dipolar couplings can ...
The N-glycan structure is illustrated according to CFG nomenclature22. MS spectra containing glycan-specific oxonium ions: m/z 204.087 (N-acetylhexosamine (HexNAc) [M + H]+), m[M/z +2 7H4].+0)9.3T(hNe-uancesptyelcniefiucrcalmeaivnaigceascpidec(iNficeiutAy cd)u-eHt2oO...
Its structure is identical to that of the amino acid aspartic acid, except that the latter compound's acidic side-chain carboxyl group has been coupled with ammonia, yielding an amide. Like glutamine, asparagine is important in the metabolism of toxic ammonia in the body. The relatively un...
Because of this common precursor, all of the side chains of these glycoproteins share the same carbohydrate core, shown within the dashed box in Figure 16-1a. Dolichols are a family of long-chain polyisoprenols that occur only in eukaryotes. They are related in structure and function to ...