It contains a α-amino group and a α-carboxylic acid group as well as a side chain carboxamide. It is classified as a polar [at physiological pH], aliphatic amino acid. It is non-essential in humans, and can undergo de novo synthesis inside the human body. From the aspect of genetic...
The amino acid L-asparagine is a structural analog of L-aspartic acid, where the side chain of the carboxylic acid moiety is amidated, to give a terminal amine group. This renders L-asparagine neutral at physiological pH. The amide group of asparagine is derived from glutamate, in the reacti...
RadicalLI is assumed to result from one-electron reduction at the amide functionalgroup in the asparagine side chain followed by protonation at theamide carbonyl oxygen by proton transfer from a neighboring moleculeacross a hydrogen bond. Radical LII is assigned to a one-electronreduction of the ...
Radical LI is assumed to result from one-electron reduction at the amide functional group in the asparagine side chain followed by protonation at the amide carbonyl oxygen by proton transfer from a neighboring molecule across a hydrogen bond. Radical LII is assigned to a one-electron reduction of...
As the side-chains of D and N residues are of equal length, the difference in PBC efficiency is likely due to differences in the gas phase acidities (螖螖Hacid 鈮 0.4 eV) of their respective side-chain functional groups: [(CO)OH] for D versus [(CO)NH2] for N. It is proposed ...
ATP and aspartate react to form a β-aspartyl-AMP intermediate17and glutamine is hydrolyzed in the other active site in a reaction for which the thiol side chain of the conserved, N-terminal cysteine (Cys-l) is required.18,19The catalytic importance ofthis cysteine places AS in the family ...
Neighboring Side Chain Effects on Asparaginyl and Aspartyl Degradation: An Ab Initio Study of the Relationship between Peptide Conformation and Backbon... The rate of spontaneous degradations of asparagine and aspartyl residues occurring through succinimide intermediates is dependent upon the nature of...
In addition, the 2′-OH group on the ribose ring hydrogen bonds to the side chain of Ser-362, consistent with the fact that dATP is not a substrate for the enzyme. At the other end of the intermediate, the α-amino group of β–aspartyl-AMP forms a salt bridge with the side chain...
and they are vital to many processes in the body as well. There are 20 main amino acids used by the body, and they all consist of a central carbon that is bonded to an amino group, a carboxyl group, a hydrogen, and a unique side chain th...
Y398C H Decrease in van der Waals interactions, solvent-accessible thiol group 24, 25, 27 R407* H Protein truncation 27 S480F CH Nonpolar residue on protein surface that may decrease solubility 28 R550C Decrease in side chain length likely to result in loss of interactions V489D CH Char...