Functional studies suggested that ASMTL-AS1 inhibits proliferation, migration, and invasion of HGC-27 and NCI-N87 cells by regulation of miR-1270. In summary, ASMTL-AS1 and miR-1270 are associated with poor prognosis of patients with gastric cancer. ASMTL-AS1 inhibited gastric cancer ...
ASMTL‐AS1 was highly expressed in RCC cell lines. Of note, UA downregulated ASMTL‐AS1 expression, and overexpressed ASMTL‐AS1 reversed the UA‐induced suppression on RCC cell migration, invasion, and tube formation. Additionally, ASMTL‐AS1 bound to HuR to maintain the stability of...
Also, ROC analysis showed that SNHG7 was a relatively good promising biomarker (AUC=0.73, p value=0.02), while ASMTL-AS1 (AUC=0.92, p value<0.0001) and LINC02604 (AUC=1.00, p value<0.0001) emerged as excellent diagnostic biomarkers in colorectal cancer.It seems that increased expression ...
Mechanistically, ASMTL-AS1 could act as a competing endogenous RNA for microRNA-342-3p (miR-342-3p) and inhibit its activity in OS cells, consequently causing an increase in ADAM metallopeptidase domain 9 (ADAM9) levels. Furthermore, inhibiting miR-342-3p or upregulating ADAM9 abated silenced...
肝癌增殖miR-660Forkhead转录因子目的 分析lncRNA ASMTL-AS1在肝癌组织中的表达水平,探讨其对肝癌细胞增殖的影响及可能的机制.方法 利用GEPIA网站分析lncRNA ASMTL-AS1在肝癌及癌旁组织中的表达情况.在lncRNAASMTL-AS1低表达的肝癌细胞中转染lncRNA ASMTL-AS1过表达载体.CCK-8检测细胞增殖情况;双荧光素酶检测ASMTL...
long non-coding RNARNA sequencingbioinformatics analysisbiomarker>DIAGNOSISDEMENTIAPROTEINGENEABSTRACTdoi:10.1080/01616412.2023.2203616View further author informationmaml166@163.comLong MaView further author informationChang YangView further author information...