In this process, the parental viral genome serves as the template and progeny DNA that is genome-length, to at most twice genome length, is produced. Newlysynthesized viral DNA may serve as the template for additional rounds of DNA replication or early transcription, or it may be transported ...
it is not essential for viral replication (Eckert et al., 2005). Therefore, it is assumed that the initial nick is produced by a host cell endonuclease. The nick provides a free 3′-OH end where nucleotides can be added by the action of the viral polymerase (E9, in VACV). Extension ...
Virus Replication In contrast to most other DNA viruses, replication of poxviruses occurs predominantly, if not exclusively, in the cytoplasm. Poxvirus entry into cells occurs by fusion of the viral membrane(s) with either the plasma or endosomal membrane, in a process that is dependent on actin...