We are a well-established employment agency with over 30 years’ experience providing contract, permanent and interim/temporary recruitment solutions to SME’s and global corporations across the UK. We continually strive to update our knowledge of our areas of expertise to provide a first class serv...
In 2021, ASC has been awarded as the top 3 in the Gllue Awards 「The Best Boutique Recruitment Firm of the Year」and top 1 in 「The Largest Deal of the Year」for the second time. In addition, we have gained「Consultant of the Year」....
ASC30 was discovered and developed in-house atAscletisas a GLP-1R biased small molecule agonist without β-arrestin recruitment. ASC30 has unique and differentiated properties that enable the administration of one small molecule as both a once-monthly subcutaneous injection and a once-daily oral tab...
Interleukin 1β (IL-1β) is critical for the in vivo survival, expansion and effector function of IL-17–producing helper T (TH17) cells during autoimmune responses, including experimental autoimmune encephalomyelitis (EAE). However, the spatiotemporal role and cellular source of IL-1β during EA...
According to an accepted theoretical model (Schroder and Tschopp, 2010), oligomerization of inflammasome receptors is followed by the recruitment of ASC that associates with procaspase-1. Procaspase-1 proteins that are in proximity undergo autocleavage and become active. The mature caspase-1 is ...
ASC has a bipartite domain structure, consisting of an N-terminal pyrin domain (PYD) and a C-terminal caspase-recruitment domain. The PYD of ASC (ASC_PYD) is known to interact with various PYD-containing intracellular danger signal sensors and PYD-only proteins. Using purified proteins, we ...
Downstream of NLRs, ASC plays an important role in the assembly of inflammasomes and the recruitment of caspase-123. To investigate the potential role of ASC in propofol-induced pyroptosis, another macrophage cell line, RAW264.7, was used, as ASC is deleted in this cell line. As shown in Fi...
5. The Group has a strong commitment to apprentice and graduate recruitment and to further developing employee skills. *Based on a currency exchange rate of $1.29. About Asia Pacific Aerospace Pty Ltd Asia Pacific Aerospace (APA) is one of the most advanced gas turbine engine Maintenance, Repai...
Medical Director Job TypeFull Time QualificationMBA/MSc/MA Experience7 years LocationLagos Job FieldMedical / Healthcare Job Brief A client of ours is seeking to hire a dedicated Medical Director to ensure the efficient operation of our healthcare facility. ...
Senior Recruitment Consultant(离职员工)-Dublin-2020年4月7日 I wouldn't recommend as they have little regards for employees, this is mainly from the management. Co workers are great. There was extensive travel required which was not taken into account when work like balance or targets were set...