ceRNAs (mRNA-miRNA-circRNA) were found to be involved in goat lactation. Therefore the findings of the current investigation suggest a novel approach through the application of a ceRNA network (mRNA-miRNA-circRNA) for the analysis of gene functionality in biological processes such as lactation....
For the identification of circRNAs associated with immunity, we used the four hub genes as key nodes to derive subnetworks of circRNA-miRNA-hub genes from the AISIRC network (Fig. 4B). Collectively, seven circRNA, three miRNA, and four gene nodes were identified within the subnetworks. Given...
Increasing evidence suggests that circular RNAs (circRNAs) play critical roles in various pathophysiological activities. However, the role of circRNAs in inflammatory bowel disease (IBD) remains unclear. Here we report the potential roles of hsa_circRNA_
Finally, we found circRNA-002178 could be delivered into CD8+ T cells to induce PD1 expression via exosomes. Taken together, our study revealed that circRNA-002178 could act as a ceRNA to promote PDL1/PD1 expression in lung adenocarcinoma. Introduction Lung cancer is...
Our investigation of the triple regulatory networks of circRNA-miRNA-mRNA in CAD revealed circ-YOD1 as a potential biomarker for CAD.doi:10.1038/s41598-019-54603-2Liu MiaoRui-Xing YinQing-Hui ZhangPei-Juan LiaoHui LiScientific Reports
BMC Genomics (2023) 24:181 https://doi.org/10.1186/s12864-023-09273-w BMC Genomics RESEARCH Open Access Analysis and verification of the circRNA regulatory network RNO_CIRCpedia_ 4214/ RNO‑miR‑667‑5p/Msr1 axis as a potential ceRNA promoting macrophage M2‑like polarization...
Therefore, it was concluded that circRNA_100859 functions as an oncogene in colon cancer by sponging the miR-217-HIF-1α pathway. In addition, the circRNA_100859-miR-217-HIF-1α axis may serve as a novel diagnostic and prognostic biomarker for patients with colon cancer. 展开 关键词: colon...
The role of circRNA in reproduction is under investigation. CircRNAs are expressed in human testis, spermatozoa (SPZ), and seminal plasma. Their involvement in embryo development has also been suggested. Asthenozoospermia, a common cause of male infertility, is characterized by reduced or absent ...
Hepatocellular carcinoma (HCC) is a common tumor characterized by high morbidity and mortality rates. The importance of circRNA in cancer diagnosis has been established. The study aimed to identify differentially-expressed circRNAs (DECs) in human blood
GNB1 is regulated by the circRNA-0133711/miR-145-5p axis in the context of breast cancer cells In a previous high-throughput sequencing study, hsa_circ_0133711 was identified as significantly upregulated in malignant breast tissues vs. normal tissues and was found to be strongly correlated with...