Drug development based on target proteins has been a successful approach in recent decades. However, the conventional structure-based drug design (SBDD) pipeline is a complex, human-engineered process with multiple independently optimized steps. Here, we
直聘ular basis. 任职要求:来自BOSS直聘• PhD or MS in Biochemistry/Biotechnology, Cell Biology, Immunology, or related field. • 0-5 years for PhD or 5-10 years for MS of industrial experience in functional biochemical, cell-based assay, and potency assay. •Strong technical innovation ...
5f). IGF2 is expressed at a very low level in differentiated cells of the haematopoietic lineage55 and detected at very low levels by RNA-seq and therefore not shown in the fold change calculation. As IGF2 has been previously shown to be regulated by silencers via chromatin interactions in ...
The isotopic distribution observed coincides with that from theoretical calculation. Figure 1c shows that GSH labeled by CH3Hg+ gave a similar result. The visible characteristic isotopic distribution is of particular significance to offer solid evidence for the labeled SH, making the MS technique a ...
The data obtained from the models of inflammatory diseases, diabetes and CRVO on animals (rabbits) is the basis for the extension of research in terms of combined in vivo models by applying the antibodies to the target tissue reactivity as close as possible. As can be seen from Table 7 and...
Cinnamon is widely used as a food spice, but due to its antibacterial and pharmacological properties, it can also be used in processing, medicine and agriculture. The word “Cinnamon” can refer to the plant, processed material, or an extract. It is sometimes used as a substance, and someti...
To investigate the cellular effects that were elicited by Angpt-1 mimetic particles, a Ca2+ mobilization assay was performed. From the literature, it is known that Angpt-1 inhibits extracellular Ca2+ influx and that vascular endothelial growth factor (VEGF) acts as its counterpart [26,27]. In...
Either Chloroquine can have a really deleterious effect on the viral charge on some patients or their QPCR assay is not valid. Even if I redo the analysis without patient#21, I don’t see any effect of Chloroquine on Viral load!
Here we report for the first time, the application of a viability qPCR (V-qPCR) method to describe the unprecedented and similar virion thermal stability of both EhV and ASFV. This result contradicts the cell culture-based assay method that suggests that virus “infectivity” is lost in a mat...
The endpoint dilution assay showed about 3 logs of difference between the nonvaccinated and vaccinated animal sera antibodies while the cytopathic assay showed about a log of A405 difference for the same sera. Although the animal protection was not shown, the vaccine candidate showed promising data...