AhR belongs to a class of transcriptional regulators that control many developmental and physiological events (e.g. xenobiotic metabolism). Our study describes AhR regulated transcriptional responses in human primary trophoblast by using the AhR agonist, 尾-naphthoflavone (BNF). Human primary ...
The aryl hydrocarbon receptor (AhR), a member of the PAS protein family, is found in organisms as diverse as Drosophila melanogaster, nematodes, and mammals. While several reviews have reported that AhR, once activated by agonist ligands, causes long-term effects such as modification of cell ...
Zinc and plant-derived ligands of the aryl hydrocarbon receptor (AHR) are dietary components affecting intestinal epithelial barrier function. Here, we explore whether zinc and the AHR pathway are linked. We show that dietary supplementation with an AHR
We have shown that environmental chemicals, such as aromatic hydrocarbon receptor (AhR) agonists, suppress B lymphopoiesis by modulating bone marrow stromal cell function. Here, we extend these studies to evaluate the potential for two prototypic AhR agonists, 7,12-dimethylbenz [a]anthracene (DMBA)...
Aryl hydrocarbon receptor (Ahr) is thought to be a crucial factor that regulates immune responses. Many Ahr-mediated immune regulatory mechanisms have been discovered, which will likely enhance our understanding of the molecular pathogenesis of autoimmune inflammation including rheumatoid arthritis (RA). ...
(AhR)- dependent regulation of pulmonary miRNA by chronic cigarette smoke exposure Sarah Rogers1, Angela Rico de Souza2, Michela Zago3, Matthew Iu1, Necola Guerrina4, Alvin Gomez5, Jason Matthews5,6 & Carolyn J. Baglole1,2,3,4 The aryl hydrocarbon receptor (AhR...
Aryl hydrocarbon receptor (AhR) was originally identified as an environmental sensor that responds to pollutants. Subsequent research has revealed that AhR recognizes multiple exogenous and endogenous molecules, including uremic toxins retained in the bo
The different effect of AhR activation on IL-6 probably depends on the type of cells and/or the AhR agonist used. Our results suggest that activation of the AhR might result in a greater IL-6 response in lung leukocytes. Although the cytokine response to FICZ stimulation in HaCaT cells is...
FICZ (6-Formylindolo[3,2-b]carbazole) is a potent aryl agonist for the hydrocarbon receptor (AhR, Kd: 70 pM). 靶点活性 AhR:70 pM (Kd) 体外活性 FICZ(0.01 nM-1 μM)单独或与50 nM MNF联用,可持续激活CYP1A1活性,通过线粒体依赖的路径引起氧化应激和细胞凋亡的激活。在HepG2细胞中,FICZ在低...
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates many of the toxic effects of dioxin-like compounds (DLCs) and