Articular cartilage functions by providing a specialized mechanically competent extracellular matrix to withstand load bearing, thus protecting the underlying bones and allowing their near friction-free articulation in the joints. The resident chondrocytes maintain this function throughout life and do so by...
In the case of a reduced biosynthetic activity, the maintenance of cartilage extracellular matrix could be impaired and may subsequently lead to a disruption of tissue integrity. A significant decrease in proteoglycan production by articular chondrocytes as a result of aging has been demonstrated (DeGr...
Cartilage also undergoes creep (the phenomenon of progressive deformation Lubrication and wear One of the functions of articular cartilage is joint lubrication. Cartilage has an extremely low co-efficient of friction, which can be further reduced by elastic deformation, synovial fluid, fluid-film format...
Synovial fluid, blood, and urine biomarkers for articular cartilage function have been long sought as these markers are potentially more sensitive than clinical imaging to offer prognosis with respect to disease evolution and response to therapy. Many different biomarkers have been investigated including ...
Articular cartilage functions as a wear-resistant, smooth, nearly frictionless, load-bearing surface. The composition and physiochemical properties of articular cartilage, the fundamental organization of the collagen network, and the molecular organization of collagen...
- functions ofcollagenfibers w/ in cartilage: - provides tensile strength to tissue and resist movement of interstitial water &proteoglycansfrom the cartilage, esp. while it sustains compressional loading; - to anchor ground substance of articular cartilage to subchondral bone; ...
This usually results in a repaired tissue of fibrocartilage that functions poorly in the loaded joint environment. Recently, autologous cultured chondrocyte transplantation and mosaic plasty were explored. We can repair small articular cartilage defects using these methods, although their effectiveness is ...
cartilage development and function.6,19–22 To gain a better understanding of the roles of Wnt/b-catenin signaling in SFZ function, we determined the cellular and molecular changes induced by activation and inactivation of Wnt/ b-catenin signaling in transgenic mice and SFZ mouse cell cultures. ...
A Review of Articular Cartilage Pathology and the Use of Glucosamine Sulfate. Provides information on the human articular cartilage. Functions of articular cartilage; Composition and structure; Categories of acute injuries to articul... James,Carey-Beth,Uhl,... - 《Journal of Athletic Training》 被...
surgery to replace the joint is frequently done to treat significant cartilage deterioration these days. However, the materials that are being used for replacement have high friction coefficients, lack shock absorption functions, ...