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‘When faced with several courses of action, people usually do what they believe is likely to have the best overall outcome. This deceptively simple sentence summarizes the theory of rational choice’ (Elster, 1989). It is a form of theorizing characterized by the use of technically rigorous mo...
Fig. 2: Engineering of pegRNA and ngRNA. a, A dual transfection/transduction experiment identifies epegRNAs as the limiting component in the v2.3 PE-eVLPs. b, Schematic of v3 PE-eVLPs utilizing the MCP–MS2 strategy for the recruitment of epegRNAs. The incorporation of MCP–MS2 strategy en...
EGFR tyrosine kinase inhibitors (TKIs) have transformed the treatment of EGFR-mutated non-small cell lung carcinoma (NSCLC); however, therapeutic resistance remains a clinical challenge. Acquired secondary EGFR mutations that increase ATP affinity and/or
Biomimetics is a branch of science that explores the technical beauty of nature. The concept of biomimetics has been brilliantly applied in famous applications such as the design of the Eiffel Tower that has been inspired from the trabecular structure of
(mRNA), which specifies the structure of a protein; the mRNA molecule then serves as a template for protein synthesis, which is carried out by complex machinery that comprises a particle called a ribosome and special adapter RNA molecules called transfer RNA.SeeDeoxyribonucleic acid (DNA),...
Treated cells were seeded in the upper part of Boyden chamber (NeuroProbe, Cabin John, MD) at a density of 1.5 × 104 cells/well in 50 μL of serum-free-medium and then incubated for 12 h at 37°C. The bottom chamber also contained standard medium with 20% fetal bovine serum....
Consequently, we developed a tool allowing the incorporation of % arbitrary bodies into meshed domains, identifying both their geometric % and material properties. % The tool relies on the MMG library \cite{mmg} that allows remeshing from a % level-set function: given the initi...
By PPD-T is meant a homopolymer resulting from mole-for-mole polymerization of p- phenylene diamine and terephthaloyl chloride and, also, copolymers resulting from incorporation of small amounts of other diamines with the p- phenylene diamine and of small amounts of other diacid chlorides with...