Kunnamo I, Kallio P, Pelkonen P, Hovi T: Clinical signs and laboratory tests in the differential diagonsis of arthritis in children. Am J Dis Child 141: 34–40, 1987. PubMedCASGoogle Scholar Giannini EH, Brewer EJ: Poor correlation between the erythrocyte sedimentation rate and clinical act...
It should be noted, however, the predictive value of these markers in clinical trials has yet to be proven and, as such, there remains a need to validate these and other new biomarkers. Indeed, caution regarding the predictive value of drug-induced declines in CTX-II has been raised by Bi...
In fact, in a recent clinical trial in France using a retrovirus to correct an X-linked SCID disorder, 3 out of 10 children developed leukemia after the vector inserted in or near a known oncogene. As a result, similar trials in the U.S. for this disorder have been halted until more ...
Clinical, laboratory and subclinical atherosclerosis assessment All 283 RA patients and 280 HC were comprehensively studied for (a) preclinical atheromatosis defined by the presence of carotid and/or femoral artery plaques in the far and near wall of eight arterial sites (left and right common, in...
Paleolog E: Target effector role of vascular endothelium in the inflammatory response: Insights from the clinical trial of anti-TNF alpha antibody in rheumatoid arthritis. Mol Pathol. 1997, 50: 225-233. PubMed PubMed Central Google Scholar Wood NC, Dickens E, Symons JA, Duff GW: In situ...
(1999). Combination therapy in early rheumatoid arthritis: a randomised, controlled, double blind 52 week clinical trial of sulphasalazine and methotrexate compared with the single components. Annals of the Rheumatic Diseases, 58, 220-5. [82] Tugwell, P., Pincus, T., Yocum, D., et al. ...
joint inflammation and burrowing behaviour were examined. We decided to evaluate burrowing behaviour as it was suggested to be a reliable tool to measure outcomes similar to those measured in the clinical trial evaluating effects of analgesics in chronic pain conditions (viz. spontaneous pain and over...
Findings In this randomized clinical trial that included 160 patients with rheumatoid arthritis in remission taking csDMARD therapy, treatment with half-dose vs stable-dose csDMARDs resulted in disease flares in 25% vs 6% over 12 months; this did not meet the noninferiority criterion of a 20%...
Recent clinical trial data add fuel to this controversy. In the Losartan Intervention For Endpoint reduction in hypertension (LIFE) study [45], baseline serum uric acid levels were associated with a 1.02-fold increase in the risk for cardiovascular events per 10 μmol/l increase; this association...
RA [31], suggest that the spectrum of arthritis severity may be associated with the degree of systemic activation of monocytes/macrophages. This is also supported by the extra-articular terminal differentiation of macrophages within rheumatoid nodules, the latter a sign of clinical severity [32,33]...