The parameters commonly measured by modern blood gas analyzers include pH; PCO2; partial pressure of O2 (PO2); concentration of hemoglobin (Hb); dyshemoglobin—COHb (carboxyhemoglobin) and MetHb (methemoglobin);
We also found that a similar increase in the acetylation profile was present in mitochondria from Sirt3WT-PASMCs exposed to either moderate (4% O2) or severe (1% O2) hypoxia. Exposure to hypoxia also caused a decrease in SIRT3 protein levels. A similar decrease in SIRT3 levels has been ...
To test this hypothesis, PASMCs were exposed to hypoxic conditions (1% O2) at different time points. The analysis of RNA revealed a significant increase in miR-30a after hypoxia for 12 h (Figure S3B). The expression of hypoxia inducible factor (HIF)-1α was increased while the expression ...
Cells were exposed to Hank’s buffered saline solution (HBSS) containing 10 mM HEPES aerated with a gas mixture of 20% O2, 5% CO2, and 75% N2 (normoxia) or 1% O2, 5% CO2, and 94% N2 (hypoxia). To prevent the entry of atmospheric oxygen, the hypoxic HBSS was tightly sealed. 2.3...
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